Suzana Radulovic, MD, Mikila R. Jacobson, PhD, Stephen R

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Presentation transcript:

Grass pollen immunotherapy induces Foxp3-expressing CD4+CD25+ cells in the nasal mucosa Suzana Radulovic, MD, Mikila R. Jacobson, PhD, Stephen R. Durham, MD, Kayhan T. Nouri-Aria, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 6, Pages 1467-1472.e1 (June 2008) DOI: 10.1016/j.jaci.2008.03.013 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Immunofluorescence staining of tonsillar sections and nasal sections from GP-IT–treated patients. A, Foxp3+CD4+ cells in the tonsil (inset shows control after preadsorption with human Foxp3 peptide, magnification ×200). B, Foxp3+CD4+ cells in the nose (magnification ×400). C, CD3+CD25+Foxp3+ cells in the tonsil (magnification ×200). D, Foxp3+CD3+CD25+ cells in the nose (magnification ×400). E and F, Foxp3+CD3+IL-10+ cells in the nose (magnification ×1000). G, Percentage of Foxp3+ cells that were CD3+, IL-10+, or CD3+IL-10+. Journal of Allergy and Clinical Immunology 2008 121, 1467-1472.e1DOI: (10.1016/j.jaci.2008.03.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Foxp3+(A), Foxp3+CD25+(B), and Foxp3+CD4+(C) cells in patients with hay fever, GP-IT–treated patients, and nonatopic control subjects. Statistical analysis was performed by using the Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2008 121, 1467-1472.e1DOI: (10.1016/j.jaci.2008.03.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions