The Primordial Thymus: Everything You Need Under One Roof

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The Primordial Thymus: Everything You Need Under One Roof Graham Anderson, Song Baik Immunity Volume 41, Issue 2, Pages 178-180 (August 2014) DOI: 10.1016/j.immuni.2014.07.012 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Emergence of Thymus Specialization for T Cell Development from a Dual-Functioning Lymphoid Organ In the primordial thymus, expression of Foxn4 results in conditions (DLL4 low, IL-7 high) that are favorable for compartmentalized T and B lymphopoiesis. Following the emergence of Foxn1 by gene duplication, expression of Dll4 increased leading to an environment that favors T lymphopoiesis over B lymphopoiesis. While such changes correlate in the ability of the thymus to support T and B lymphopoiesis, the nature of thymus-colonizing cells and the ability of the thymus to impose or reveal T cell potential, remain unclear. Immunity 2014 41, 178-180DOI: (10.1016/j.immuni.2014.07.012) Copyright © 2014 Elsevier Inc. Terms and Conditions