Preliminary experience with a novel fluorescence lymphography using indocyanine green in patients with secondary lymphedema  Naoki Unno, MD, Kazunori.

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Preliminary experience with a novel fluorescence lymphography using indocyanine green in patients with secondary lymphedema  Naoki Unno, MD, Kazunori Inuzuka, MD, Minoru Suzuki, MD, Naoto Yamamoto, MD, Daisuke Sagara, MD, Motohiro Nishiyama, MD, Hiroyuki Konno, MD  Journal of Vascular Surgery  Volume 45, Issue 5, Pages 1016-1021 (May 2007) DOI: 10.1016/j.jvs.2007.01.023 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 A, The device used in this study. The image can be observed at the monitor of the laptop computer, and the images were recorded on the hard disk. B, Acquisition of images of fluorescent lymphography at the bedside. The instrument is equipped with a charge-coupled device camera and light-emitting diode, and is easy to use. Journal of Vascular Surgery 2007 45, 1016-1021DOI: (10.1016/j.jvs.2007.01.023) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 A and B, Normal fluorescent lymphography in healthy volunteers. Panoramic image shows continuous lymph channels from the injection site at the foot to the groin along the medial aspect of thigh. Journal of Vascular Surgery 2007 45, 1016-1021DOI: (10.1016/j.jvs.2007.01.023) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 Characteristic pattern of fluorescent lymphography in patients with secondary lymphedema. A, Dermal backflow. B, Extended fluorescent images at the dorsum and plantar region of the foot. C, Dilated lymph channels with proximal obliteration. D, Diffuse glittering of fluorescent signals with scattered twinkling of the dye. Journal of Vascular Surgery 2007 45, 1016-1021DOI: (10.1016/j.jvs.2007.01.023) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 4 A, A 70-year-old woman with right lower extremity lymphedema who underwent hysterectomy, bilateral iliac node dissection, and pelvic radiotherapy for uterine cancer 30 years earlier (clinical stage III). B, Lymphoscintigram shows extensive dermal pattern in the right leg. C, Indocyanine green fluorescence lymphogram shows diffuse dermal backflow, extended fluorescent images at the dorsum and plantar region of the right foot, and Milky Way sign. Journal of Vascular Surgery 2007 45, 1016-1021DOI: (10.1016/j.jvs.2007.01.023) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 5 A, A 69-year-old woman with left lower extremity lymphedema who underwent hysterectomy, bilateral iliac dissection and pelvic radiotherapy for uterine cancer 12 years earlier (clinical stage II). B, Lymphoscintigram shows markedly delayed transport with dermal pattern in the left leg with diminished number of lymph nodes in the left inguinal region. C, Indocyanine green fluorescence lymphogram shows diffuse dermal backflow in the left leg. Journal of Vascular Surgery 2007 45, 1016-1021DOI: (10.1016/j.jvs.2007.01.023) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions