Association of Polymorphisms in the Angiotensin-Converting Enzyme Gene with Alzheimer Disease in an Israeli Arab Community Yan Meng, Clinton T. Baldwin,

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Presentation transcript:

Association of Polymorphisms in the Angiotensin-Converting Enzyme Gene with Alzheimer Disease in an Israeli Arab Community Yan Meng, Clinton T. Baldwin, Abdalla Bowirrat, Kristin Waraska, Rivka Inzelberg, Robert P. Friedland, Lindsay A. Farrer The American Journal of Human Genetics Volume 78, Issue 5, Pages 871-877 (May 2006) DOI: 10.1086/503687 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 1 LD block structure in the DCP1 region. The upper triangle shows LD calculated using the r2 measure, and the lower triangle shows LD calculated using the D′ measure. The American Journal of Human Genetics 2006 78, 871-877DOI: (10.1086/503687) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 2 Proposed mechanisms for influence of ACE on development of AD via a pathway leading to increased production of the toxic form of Aβ (Aβ42) or through the action of vascular risk factors (see text for details). The American Journal of Human Genetics 2006 78, 871-877DOI: (10.1086/503687) Copyright © 2006 The American Society of Human Genetics Terms and Conditions