GLP-1–Based Therapies: The Dilemma of Uncertainty

Slides:

Advertisements

Similar presentations

Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells Lin Wang, Xiangdong Wang, Lei.

Advertisements

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP CHEST

Hypoglycemia After Gastric Bypass: The Dark Side of GLP-1

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Pancreatic Fusion Abnormality Found During a Whipple Procedure

Stuart Jon Spechler, Rhonda F. Souza Gastroenterology

Insulin-Like Growth Factor-1 Is Not Essential for the Intestinal Trophic Effects of Glucagon-Like Peptide-2 Prue Pereira–Fantini, Sarah Thomas, Julie.

Volume 143, Issue 5, Pages (November 2012)

Complications of Proton Pump Inhibitor Therapy

Volume 152, Issue 4, Pages (March 2017)

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4

The Incretins and β-Cell Health: Contrasting Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 as a Path to Understand Islet Function.

Christoph Lübbert, Babett Holler Gastroenterology

Gerard Karsenty, Michael D. Gershon Gastroenterology

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer

Hypoglycemia After Gastric Bypass: The Dark Side of GLP-1

Unmasking Pancreatic Cancer: Epitope Spreading After Single Antigen Chimeric Antigen Receptor T-Cell Therapy in a Human Phase I Trial Max Heckler, Stephanie.

Do Diabetes Drugs Modify the Risk of Pancreatic Cancer?

Genetics and Genomics in the Practice of Medicine

Is HCV Infection a Neurologic Disorder?

Outcomes Among Living Liver Donors

Personalizing Therapy for Colorectal Cancer

Covering the Cover Gastroenterology

Ira J. Fox, Stephen C. Strom Gastroenterology

Pancreatic Fusion Abnormality Found During a Whipple Procedure

Gastroenterology 2011–2016: Looking Back and Forward

Making Sense of HDAC2 Mutations in Colon Cancer

Stuart Jon Spechler, Rhonda F. Souza Gastroenterology

Personalizing Therapy for Colorectal Cancer

Volume 141, Issue 1, Pages (July 2011)

Clinical Challenges and Images in GI

Unusual Case of an Upset Stomach

Volume 153, Issue 3, Pages e16-e17 (September 2017)

Volume 135, Issue 4, Pages (October 2008)

A Historical Perspective on Clinical Advances in Pancreatic Diseases

Volume 150, Issue 4, Pages (April 2016)

Toru Furukawa Clinical Gastroenterology and Hepatology

Kenneth E.L. McColl, Derek Gillen Gastroenterology

Volume 145, Issue 1, Pages (July 2013)

Colon Cancer: An Update and Future Directions

Volume 137, Issue 1, Pages (July 2009)

Volume 145, Issue 1, Pages (July 2013)

Volume 155, Issue 6, Pages (December 2018)

Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer Thomas Winder, Heinz–Josef.

Coffee and Colorectal Cancer: Grounds for Prevention?

Rafael Esteban, Maria Buti Gastroenterology

Volume 150, Issue 7, Pages (June 2016)

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Volume 148, Issue 3, Pages (March 2015)

Methionine Intake and Pancreatic Cancer Risk: Digesting the Evidence

Volume 150, Issue 7, Pages (June 2016)

The Rise and Fall (and Rise?) of Endoscopic Anti-Reflux Procedures

Jikyoung Lee, Jong Jin Hyun, Hong Sik Lee Gastroenterology

Covering the Cover Gastroenterology

The Dawning of a New Editorial Board for Gastroenterology

Volume 156, Issue 4, Pages (March 2019)

Volume 139, Issue 1, Pages (July 2010)

Changing of the Guards: 2011–2016 Gastroenterology Team

A “Crescent-in-doughnut” Lesion at Right Lower Quadrant Abdomen

Volume 156, Issue 4, Pages (March 2019)

Volume 148, Issue 4, Pages (April 2015)

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Cancer Costs Projected to Reach at Least $158 Billion in 2020

Volume 138, Issue 6, Pages (May 2010)

Reinvesting in US Biomedical Research—The Time is Now

Electronic Clinical Challenges and Images in GI

The Future of Endoscopic Retrograde Cholangiopancreatography

Controversies in Liver Transplantation for Hepatitis C

Presentation transcript:

GLP-1–Based Therapies: The Dilemma of Uncertainty Joachim Spranger Gastroenterology Volume 141, Issue 1, Pages 20-23 (July 2011) DOI: 10.1053/j.gastro.2011.05.019 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 GLP-1 agonists increase β-cell mass in rodents. GLP-1–dependent effects on β-cell proliferation include activation of phosphatidylinositol-3 (PI3) kinase, AKT, mitogen-activated protein kinase (MAPK), protein kinase Cζ, the src kinase, and the epidermal growth factor receptor.15 Similar trophic mechanisms have been implicated in the pathogenesis of pancreatic cancer and activation of those mechanisms in cancer progenitor cells might be detrimental. Gastroenterology 2011 141, 20-23DOI: (10.1053/j.gastro.2011.05.019) Copyright © 2011 AGA Institute Terms and Conditions