App‐CTFs accumulate in the neurites and synaptic compartments in Aph1abc cKO Cre+ brains App‐CTFs accumulate in the neurites and synaptic compartments.

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App‐CTFs accumulate in the neurites and synaptic compartments in Aph1abc cKO Cre+ brains App‐CTFs accumulate in the neurites and synaptic compartments in Aph1abc cKO Cre+ brains Immunostaining with an antibody recognizing the C‐terminal part of App. Sagittal brain slices from App KO mice were used to show the specificity of the antibody. Conditional deletion of the Aph1 genes in the pyramidal neurons causes accumulation of App‐CTFs in the neurites in the hippocampal and cortical areas. Zoom‐ins on the dentate gyrus (DG) and CA3 region of the hippocampus and the parietal cortex overlying the hippocampus show that expression of App and App‐CTFs is mainly confined to the neuronal somata in control brains, whereas App‐CTFs accumulate in the neurites and synaptic compartments in Aph1abc cKO Cre+ brains. Scale bar for left panels = 390 μm; scale bar for central panels = 150 μm; scale bar for right panels = 110 μm. Hermien Acx et al. EMBO Mol Med. 2017;emmm.201707561 © as stated in the article, figure or figure legend