Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: Consequences for FK506 assimilation Wim P.D. Lemahieu, Bart D. Maes, Kristin.

Slides:

Advertisements

Similar presentations

Renal involvement in hepatitis C infection: Cryoglobulinemic glomerulonephritis Giuseppe D’Amico Kidney International Volume 54, Issue 2, Pages

Advertisements

Ischemic heart disease after renal transplantation

Volume 59, Issue 3, Pages (March 2001)

Pathophysiology of renal fluid retention

Epoetin use and Kidney Disease Outcomes Quality Initiative hemoglobin targets in patients returning to dialysis with failed renal transplants C.A. Solid,

Volume 69, Issue 5, Pages (March 2006)

Michael D. Gautreaux, Barry I. Freedman Kidney International

Role of diuretics in the preservation of residual renal function in patients on continuous ambulatory peritoneal dialysis James F. Medcalf, Kevin P.G.

Volume 83, Issue 3, Pages (March 2013)

Early Cytomegalovirus Reactivation Leaves a Specific and Dynamic Imprint on the Reconstituting T Cell Compartment Long-Term after Hematopoietic Stem Cell.

Volume 85, Issue 2, Pages (January 2014)

Volume 85, Issue 6, Pages (June 2014)

Volume 68, Issue 6, Pages (December 2005)

Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation Karthik K. Tennankore, S. Joseph Kim, Ian P.J.

Pathophysiology of renal fluid retention

Response to is the reduction in urea distribution volume over time in clinically stable dialysis patients real? S. Andrulli, S. Di Filippo, F. Locatelli

Volume 85, Issue 3, Pages (March 2014)

Volume 63, Issue 3, Pages (March 2003)

The progression of chronic kidney disease: A 10-year population-based study of the effects of gender and age B.O. Eriksen, O.C. Ingebretsen Kidney International

Volume 62, Issue 1, Pages (July 2002)

Methotrexate in the urine

Volume 66, Issue 5, Pages (November 2004)

Comorbidity and confounding in end-stage renal disease

Volume 14, Issue 11, Pages (March 2016)

Volume 70, Issue 11, Pages (December 2006)

Volume 55, Issue 4, Pages (April 1999)

Preservation of the kidney by carbon monoxide: a black swan phenomenon

Edmund G. Lowrie Kidney International

Volume 77, Pages S8-S11 (March 2010)

Volume 71, Issue 6, Pages (March 2007)

Prospective randomized study of individual and group psychotherapy versus controls in recipients of renal transplants1 Lyndsay S. Baines, John T. Joseph,

Volume 70, Issue 12, Pages (December 2006)

Pharmacokinetic Evaluation of the Drug Interaction between Intravenous Itraconazole and Intravenous Tacrolimus or Intravenous Cyclosporin A in Allogeneic.

David Del Bello, Michael J. Ross, Shirish S. Huprikar

Blood pressure targets in hemodialysis patients

Volume 67, Issue 1, Pages (January 2005)

Volume 62, Issue 1, Pages (July 2002)

Günter Weiss, Florian Kronenberg Kidney International

Volume 66, Issue 2, Pages (August 2004)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Tilman B. Drüeke, Ziad A. Massy Kidney International

Volume 76, Issue 8, Pages (October 2009)

Volume 71, Issue 12, Pages (June 2007)

Volume 69, Issue 5, Pages (March 2006)

Evidence for impaired assimilation of protein in chronic renal failure

Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients B. Bammens, P. Evenepoel, H. Keuleers,

Long-term survival in renal transplant recipients with graft function

Volume 79, Issue 5, Pages (March 2011)

Racial differences in survival of patients on dialysis

Kar Neng Lai, Andrew S H Lai, Desmond Y H Yap, Matthew M T Ng

Epoetin use and Kidney Disease Outcomes Quality Initiative hemoglobin targets in patients returning to dialysis with failed renal transplants C.A. Solid,

Organ transplantation goes to the movies

Removal of middle molecules and protein-bound solutes by peritoneal dialysis and relation with uremic symptoms Bert Bammens, Pieter Evenepoel, Kristin.

Volume 65, Issue 5, Pages (May 2004)

Volume 63, Issue 6, Pages (June 2003)

Volume 58, Issue 3, Pages (September 2000)

Vikas R. Dharnidharka, Michael E. Seifert Kidney International

Volume 69, Issue 10, Pages (May 2006)

Volume 74, Issue 7, Pages (October 2008)

Urinalysis in Western culture: A brief history

Volume 87, Issue 3, Pages (March 2015)

Volume 70, Issue 5, Pages (September 2006)

Ischemic heart disease after renal transplantation

The international realities of live donor kidney transplantation

Strategies for iron supplementation: Oral versus intravenous

S. Dmitrienko, A. Yu, R. Balshaw, R.J. Shapiro, P.A. Keown

Prediction in idiopathic membranous nephropathy

Attitudes and predictive factors for live kidney donation: A comparison of live kidney donors versus nondonors Lynn Stothers, William A. Gourlay, Li.

Ronen Levi, Justin Silver Kidney International

Presentation transcript:

Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: Consequences for FK506 assimilation Wim P.D. Lemahieu, Bart D. Maes, Kristin Verbeke, Yves Vanrenterghem Kidney International Volume 67, Issue 3, Pages 1152-1160 (March 2005) DOI: 10.1111/j.1523-1755.2005.00182.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Difference of mean (±SEM) dose/weight normalized tacrolimus trough level (BCI) before (white box) versus after (black box) switch from cimetidine to omeprazole in 48 renal transplant recipients in whom ulcer prophylaxis with cimetidine was changed to omeprazole. Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Difference of mean (±SEM) dose/weight normalized tacrolimus trough level (BCI) before (white box) versus after (black box) cessation of cimetidine in 102 renal transplant recipients in whom ulcer prophylaxis with cimetidine was never switched to omeprazole. Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Median breath recovery curves of 13/14C after 13C-aminopyrin (reflecting overall CYP, A), after intravenous 14C-erythromycin (reflecting hepatic CYP3A4, B), and after deconvolution of measurements obtained by per oral and intravenous administration of 14C-erythromycin (reflecting intestinal CYP3A4, C), at baseline (⋄), after cimetidine (▴), omeprazole (x), and ranitidine (▪). Left side: 13/14C recovery rate (dose%/h); right side: cumulative 13/14C recovery (dose%). Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Median cumulative 14C recovery (dose%) in urine (inversely reflecting PGP activity), after intravenous (A) and after deconvolution of measurements obtained by oral and intravenous 14C-erythromycin (B) at baseline (⋄), after cimetidine (▴), omeprazole (x), and ranitidine (▪). Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Relative changes in overall CYP (A) and hepatic (left) and intestinal (right) CYP3A4 activity (B) and hepatic (left) and intestinal (right) PGP activity (C) based on comparison of total 13C recovery from the ABT and total 14C recovery from the iv and deconvolved EBT and EUT observed at baseline (= 100%, white), and after cimetidine (black), omeprazole (light shade), and ranitidine (dark shade). Bars represent interquartile range. *P < 0.05 for comparison with baseline by means of nonparametric ANOVA and subsequent Wilcoxon signed rank test. Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 6 Potential interaction mechanisms of tacrolimus and omeprazole or cimetidine. Full arrows: effects of omeprazole; dashed arrows in light shade: effects of cimetidine. Kidney International 2005 67, 1152-1160DOI: (10.1111/j.1523-1755.2005.00182.x) Copyright © 2005 International Society of Nephrology Terms and Conditions