Improving the Management of COPD in Women

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Presentation transcript:

Improving the Management of COPD in Women Christine R. Jenkins, MD, Kenneth R. Chapman, MD, James F. Donohue, MD, Nicolas Roche, MD, Ioanna Tsiligianni, MD, MeiLan K. Han, MD CHEST Volume 151, Issue 3, Pages 686-696 (March 2017) DOI: 10.1016/j.chest.2016.10.031 Copyright © 2016 The Authors Terms and Conditions

Figure 1 The impact of female sex on COPD.4,11,20,24,27-30,32,37,38,49-53,55,56,58-61,63,64,67,68,90,91 CHEST 2017 151, 686-696DOI: (10.1016/j.chest.2016.10.031) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Age-adjusted relative risk of hospitalization for COPD according to pack-years among smokers who inhaled, in the Copenhagen City Heart Study (n = 9,083). Lifelong nonsmokers and smokers who did not inhale were used as reference.16Note the logarithmic scale. (Reproduced with permission of the European Respiratory Society ©. European Respiratory Journal, Apr 1997;10(4):822-827; DOI: 10.1183/09031936.97.10040822.) CHEST 2017 151, 686-696DOI: (10.1016/j.chest.2016.10.031) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Kaplan-Meier graph of time to first moderate to severe exacerbation in the Towards a Revolution in COPD Health (TORCH) study (n = 1,481 women; n = 4,631 men).49 Bars represent SE. (Reprinted with permission of the American Thoracic Society. Copyright © 2016 American Thoracic Society. Celli B, Vestbo J, Jenkins CR, Jones PW, Ferguson GT, Calverley PM, Yates JC, Anderson JA, Willits LR, Wise RA; Investigators of the TORCH Study. Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience. Am J Respir Crit Care Med. 2011;183(3):317-322. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.) CHEST 2017 151, 686-696DOI: (10.1016/j.chest.2016.10.031) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Mean St George’s Respiratory Questionnaire (SGRQ) scores according to sex (∗P < .05) in a study that included 90 patients with COPD (60 male subjects and 30 female subjects; mean age: 64 ± 9 years) with a wide range of airway obstruction disorders (mean FEV1: 56% ± 19% of predicted).62 (Reproduced under Creative Commons license CC BY-NC from Ferrari R, Tanni SE, Lucheta PA, Faganello MM, do Amaral RA, Godoy I. [Gender differences in predictors of health status in patients with COPD]. J Bras Pneumol. 2010;36(1):37-43.) CHEST 2017 151, 686-696DOI: (10.1016/j.chest.2016.10.031) Copyright © 2016 The Authors Terms and Conditions