Volume 92, Issue 5, Pages (March 1998)

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Volume 92, Issue 5, Pages 593-596 (March 1998) Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance Barbara B Kahn Cell Volume 92, Issue 5, Pages 593-596 (March 1998) DOI: 10.1016/S0092-8674(00)81125-3

Figure 1 Insulin Signaling Pathways IRSs, insulin responsive substrates; PDKs, phosphoinositide-dependent protein kinases; GSK3, glycogen synthase kinase 3; Akt/PKB, protein kinase B; p110, catalytic subunit; p85, regulatory subunit of phosphoinositide 3-kinase. Dotted lines indicate effects that are still under investigation. Cell 1998 92, 593-596DOI: (10.1016/S0092-8674(00)81125-3)