DLC1 and Liver Cancer: The Akt Connection

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DLC1 and Liver Cancer: The Akt Connection Torsten Wuestefeld, Lars Zender Gastroenterology Volume 139, Issue 4, Pages 1093-1096 (October 2010) DOI: 10.1053/j.gastro.2010.08.016 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Schematic representation of a model suggesting 2 independent tumor suppressive functions mediated by DLC1. (A) Loss of DLC1 expression through genomic deletion or promoter hypermethylation enhances hepatocarcinogenesis via increased RhoA signaling. (B) DLC1 phosphorylation by AKT can promote tumorigenesis without affecting DLC1's function as a RhoGTPase activating protein. Gastroenterology 2010 139, 1093-1096DOI: (10.1053/j.gastro.2010.08.016) Copyright © 2010 AGA Institute Terms and Conditions