Volume 140, Issue 4, Pages 1174-1181 (April 2011) 5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer  Rodrigo Jover, Thuy–Phuong Nguyen, Lucía Pérez–Carbonell, Pedro Zapater, Artemio Payá, Cristina Alenda, Estefanía Rojas, Joaquín Cubiella, Francesc Balaguer, Juan D. Morillas, Juan Clofent, Luis Bujanda, Josep M. Reñé, Xavier Bessa, Rosa M. Xicola, David Nicolás–Pérez, Antoni Castells, Montserrat Andreu, Xavier Llor, C. Richard Boland, Ajay Goel  Gastroenterology  Volume 140, Issue 4, Pages 1174-1181 (April 2011) DOI: 10.1053/j.gastro.2010.12.035 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Kaplan–Meier survival curves depicting the effect of CIMP status on DFS in (A) the entire series of CRCs and (B) patients with TNM stage II and III CRCs. Vertical tick marks indicate censored events. Gastroenterology 2011 140, 1174-1181DOI: (10.1053/j.gastro.2010.12.035) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Kaplan–Meier survival curves showing the effect of CIMP status on survival according to 5-FU–based chemotherapy treatment. (A) In patients with CIMP-negative tumors, adjuvant chemotherapy clearly provides a survival benefit with a higher probability of DFS (log-rank 0.00001). (B) In patients with CIMP-positive tumors, the use of 5-FU–based adjuvant chemotherapy does not improve DFS (log-rank 0.7). Vertical tick marks indicate censored events. Gastroenterology 2011 140, 1174-1181DOI: (10.1053/j.gastro.2010.12.035) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 Kaplan–Meier survival curves indicating the effect of chemotherapy on survival according to CIMP status. (A) In patients who received 5-FU–based adjuvant chemotherapy, the existence of a CIMP-positive tumor confers a worse prognosis, with lower DFS (log-rank 0.02). (B) In contrast, in patients who did not receive adjuvant chemotherapy, the situation reverses, and those with CIMP-positive tumors had a better prognosis (log-rank 0.04). Vertical tick marks indicate censored events. Gastroenterology 2011 140, 1174-1181DOI: (10.1053/j.gastro.2010.12.035) Copyright © 2011 AGA Institute Terms and Conditions