An Integrated Usage and Acquisition Process for Reducing Specialty Rx Program Costs HR Specialty Products & Services Catalogue Executive Summary A No Frills Distillation of Vendor’s Marketing Collateral Thomas A Ference President & CEO Human Resources Mining & Distribution Co Locating, Validating and Accelerating HR  Innovation   Office: 219-662-0201 Cell: 630-240-2583 Fax: 219-661-0236 e-mail: tference@hrmdco.com Website: www.hrmdco.com

Specialty Rx Integrated Usage and Acquisition Process Many specialty drugs are being prescribed on an experimental basis for diagnoses where the use of the drug has not been tested and /or where the drug has been shown that it does not work for many / the majority of patients based on clinical trial results. To solve these problems, a management process was developed by veterans of the pharmaceutical and related industries to manage the patient’s access to and supply of specialty drugs. The process begins by assuring appropriate usage based on label instructions vs experimentation by the prescribing physician.

Specialty Rx Integrated Usage and Acquisition Process Drug effectiveness is then proven out by testing and measuring to know when and for which patients a given drug can actually work. Once a drug is shown to be appropriate and effective, an automated acquisition process assures the best price and delivery method. No changes to existing plan or benefit design Start program at any time Actual savings range from 15% to 25% of specialty drug costs and can be estimated in advance by analyzing the employer’s specialty Rx data.

Many Drugs Don’t Work for Most People Humira FDA approval is defined as a 20% improvement in ACR score . Humira in Clinical Trials Enbrel, Helps 1 in 4 Copaxone, Helps 1 in 16 Neulasta, Helps 1 in 15

Clinical Analytics Leverage a Continuous Improvement Care Model Observe Orient Decide Act Establish baselines using clinical trial and cost data Update clinical models Test and track effectiveness of prescribed therapies Create new insights on aggregate data using machine learning

Two Case Studies – Cost Savings 4,600 Members 64,000 Members $0.7M Net Savings Millions Before After ` Contract Discount Supply Savings Clinical Savings Rebates

Next Steps This product/service is contained in the HR Specialty Products & Services Catalogue™ Operational level details about this particular service provider can be obtained in conference with the vendor The HR Mining &Distribution Co. is an independent and contracted representative of the vendor Upon your request, we will arrange for an introduction that can range from a simple, quick conference call to a services overview / system demo Tom Ference 219-662-0201 (Chicagoland area) or tference@hrmdco.com Thank you for your potential interest in this fresh thinking