Volume 128, Issue 4, Pages (April 2005)

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Volume 128, Issue 4, Pages 1081-1088 (April 2005) Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis John M. Mariadason, Courtney Nicholas, Kaitlin E. L’Italien, Min Zhuang, Helena J.M. Smartt, Barbara G. Heerdt, Wancai Yang, Georgia A. Corner, Andrew J. Wilson, Lidija Klampfer, Diego Arango, Leonard H. Augenlicht Gastroenterology Volume 128, Issue 4, Pages 1081-1088 (April 2005) DOI: 10.1053/j.gastro.2005.01.054 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Validation of tissue fractionation. (A) Localization of PCNA to the small intestinal crypts. (B) PCNA expression and (C) ALP activity along the CVA. (D) Expression profiles of established markers of absorptive and Paneth cell differentiation along the CVA. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Altered expression of cell-cycle genes along the CVA. Gene expression data from the F1 (villus tip) versus F10 (crypt) experiment were superimposed onto the cell cycle pathway map using the GenMapp software. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Altered expression of genes involved in (A) RNA processing, (B) translation initiation and elongation, (C) transfer RNA synthesis, (D) protein folding, and (E) ribosomal structure. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 Altered expression of (A) cytoskeletal genes and (B) genes involved in lipid uptake and transport. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 5 Validation of changes in expression of cell cycle (top panel) and cytoskeletal genes (middle panel) by Western blot. Tubulin served as a loading control. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 6 Altered expression of (A) β-catenin/TCF target genes and (B) potential regulators of Wnt signaling. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 7 Expression of (A) MYC, MAD, and MAX messenger RNA and (B) protein along the CVA. Gastroenterology 2005 128, 1081-1088DOI: (10.1053/j.gastro.2005.01.054) Copyright © 2005 American Gastroenterological Association Terms and Conditions