Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time Kadri Rekker, M.Sc.,

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Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time Kadri Rekker, M.Sc., Merli Saare, M.Sc., Anne Mari Roost, M.Sc., Tanel Kaart, Ph.D., Deniss Sõritsa, M.D., Helle Karro, M.D., Ph.D., Andrei Sõritsa, M.D., Ph.D., Carlos Simón, M.D., Ph.D., Andres Salumets, Ph.D., Maire Peters, Ph.D. Fertility and Sterility Volume 104, Issue 4, Pages 938-946.e2 (October 2015) DOI: 10.1016/j.fertnstert.2015.06.029 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Relative miRNA levels in plasma: (A) miR-200a; (B) miR-200b; (C) miR-141. Values are presented as mean ± SD; results of pairwise comparisons were corrected for multiple testing with the use of the TukeyKramer method, and only P values corresponding to statistically significant differences (P≤.05) are shown. For illustrative purposes, the group means of ΔCt values were multiplied by −1. Fertility and Sterility 2015 104, 938-946.e2DOI: (10.1016/j.fertnstert.2015.06.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 miRNA level alterations in paired blood samples of healthy individuals taken in the evening (n = 8) and morning (n = 8). The relative miRNA levels were 2.8-, 2.7- and 2.5-fold lower in the morning for miR-200a, miR-200b, and miR-141, respectively (P<.01). For illustrative purposes, the group means of ΔCt values were multiplied by −1. Fertility and Sterility 2015 104, 938-946.e2DOI: (10.1016/j.fertnstert.2015.06.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Receiver operating characteristic (ROC) curve analysis of plasma miRNAs. Area under the ROC curve (AUC), sensitivity (SN), and specificity (SP) for (A) miR-200a, (B) miR-200b, (C) miR-141, and (D) the combination of these miRNAs were calculated based on the data from women with endometriosis (n = 32) and patients with similar complaints but without the disease (n = 24). Fertility and Sterility 2015 104, 938-946.e2DOI: (10.1016/j.fertnstert.2015.06.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions