Spherical harmonic representation of anatomical boundary

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Presentation transcript:

Spherical harmonic representation of anatomical boundary Moo K. Chung Department of Statistics Department of Biostatistics and Medical Informatics Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison http://www.stat.wisc.edu/~mchung

Spherical harmonic (SPHARM) representation is a smooth basis function expansion on unit sphere measurement basis function expansion sub.1 sub.2

SPHARM for specific degrees

Previous brute force approach. Due to a memory problem, SPHARM over degree 40 was not possible.

SPHARM representation of the cortex

Average template cortex is constructed by averaging the SPHARM coefficients.

SPHARM of noisy cortical thickness

What do we do with this new technique? 1. Hippocampus and amygdala shape analysis in autism 2. HRF modeling on cortical surface

SPHARM representation of hippocampus – Shubing Wang Overfitting degree 1 degree 5 degree 10 degree 50

Volume rendering of manual segmentation of a normal subject (from an old study). Left hippocampus Right hippocampus

Marching cubes algorithm for manual segmentation

Manual segmentation Improved estimation

Superimposition of the manual to our active contour based result. Underestimate the manual segmentation.