HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8–positive plasmablastic lymphoma by Nicolas Dupin, Tim L.

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HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8–positive plasmablastic lymphoma by Nicolas Dupin, Tim L. Diss, Paul Kellam, Micheline Tulliez, Ming-Qing Du, Didier Sicard, Robin A. Weiss, Peter G. Isaacson, and Chris Boshoff Blood Volume 95(4):1406-1412 February 15, 2000 ©2000 by American Society of Hematology

Cases 19, 7, and 8.(A) and (B): A lymph node from case 19 shows features of plasma cell variant CD (panels A and B). Cases 19, 7, and 8.(A) and (B): A lymph node from case 19 shows features of plasma cell variant CD (panels A and B). (A) Follicle comprises a hyalinized germinal center surrounded by a broad mantle. (B) High magnifcation showing uniform population of small lymphocytes in the mantle zone. (C) and (D): A lymph node from case 7, an HIV-positive patient, shows features of plasmablastic variant CD. (C) The follicle comprises a partially hyalinized germinal center surrounded by a well-formed mantle. (D) High magnification of mantle zone showing small lymphocytes and scattered transformed plasmablasts, 2 of which are arrowed. (E) and (F): A lymph node from case 8, an HIV-positive patient with plasmablastic CD. (E) The follicle shows a poorly defined mantle zone that is partially replaced by a concentric infiltrate of plasmablasts. (F) High magnification of area within the rectangle in Figure 1E, showing the germinal center (GC) surrounded by plasmablasts that have replaced the mantle. Some cells in mitosis are highlighted in squares. Nicolas Dupin et al. Blood 2000;95:1406-1412 ©2000 by American Society of Hematology

Case 10, lymph node from an HIV-negative patient stained for HHV-8 Case 10, lymph node from an HIV-negative patient stained for HHV-8.(A) Low magnification showing mantle zone distribution of HHV-8–positive cells. Case 10, lymph node from an HIV-negative patient stained for HHV-8.(A) Low magnification showing mantle zone distribution of HHV-8–positive cells. (B) High magnification showing stippled and/or diffuse nuclear staining. Inset shows a cell in mitosis; there is localization of HHV-8 DNA to chromosomes by antiLNA antibody. Nicolas Dupin et al. Blood 2000;95:1406-1412 ©2000 by American Society of Hematology

Cases 8 and 10.(A-E): Case 8. Cases 8 and 10.(A-E): Case 8. Follicle and interfollicular plasma cells stained (A) for HHV-8, (B) for μ heavy chain, (C) for κ light chain, (D) for λ light chain, and (E) with Ki-67. The mantle zone plasmablasts show nuclear positivity for HHV-8, express μ heavy chain, and show λ light-chain restriction, while the μ negative interfollicular plasma cells are polytypic with respect to light chains. Most, if not all, of the plasmablasts are in cycle. (F) Case 10. Mantle zone immunoblasts double-stained for HHV-8 (blue) and λ light chain (brown). HHV-8–positive nuclei are exclusively within λ-positive cells. Nicolas Dupin et al. Blood 2000;95:1406-1412 ©2000 by American Society of Hematology

Case 1.Section of spleen showing (A) a microlymphoma surrounding a splenic arteriole comprising (B) HHV-8–positive cells with (C) plasmablastic morphology. Case 1.Section of spleen showing (A) a microlymphoma surrounding a splenic arteriole comprising (B) HHV-8–positive cells with (C) plasmablastic morphology. (D) Immunostain for κ (left) and λ (right); there is λ light-chain restriction. Nicolas Dupin et al. Blood 2000;95:1406-1412 ©2000 by American Society of Hematology

Case 5.(A) Lymph node showing frank plasmablastic lymphoma, (B) immunostained for HHV-8 and (C) for κ (left) and λ (right) light chains. Case 5.(A) Lymph node showing frank plasmablastic lymphoma, (B) immunostained for HHV-8 and (C) for κ (left) and λ (right) light chains. The HHV-8–positive lymphoma cells show λ light-chain restriction. (D) Polyacrylamide gel electrophoresis of immunoglobulin heavy-chain gene PCR products. Lane 1: PhiXHinfI molecular weight markers (the marker band immediately below the positive control band is 82bp variant CD). Lane 2: positive control B-cell lymphoma. Lane 3: negative control (no DNA). Lanes 4, 5, and 6: repeat amplifications of DNA showing a reproducible dominant band indicating an expanded clone. Nicolas Dupin et al. Blood 2000;95:1406-1412 ©2000 by American Society of Hematology