Antidepressant Therapy in Patients Undergoing Coronary Artery Bypass Grafting: The MOTIV-CABG Trial Sidney Chocron, MD, PhD, Pierre Vandel, MD, PhD,

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Antidepressant Therapy in Patients Undergoing Coronary Artery Bypass Grafting: The MOTIV-CABG Trial Sidney Chocron, MD, PhD, Pierre Vandel, MD, PhD, Camille Durst, MD, Frédéric Laluc, MD, Djamel Kaili, MD, Michael Chocron, PhD, Joseph-Philippe Etievent, MD The Annals of Thoracic Surgery Volume 95, Issue 5, Pages 1609-1618 (May 2013) DOI: 10.1016/j.athoracsur.2013.02.035 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Study flowchart by treatment group. (BDI = Beck Depression Inventory Short Form; ITT = intention-to-treat.) The Annals of Thoracic Surgery 2013 95, 1609-1618DOI: (10.1016/j.athoracsur.2013.02.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Change from baseline in Beck Depression Inventory (BDI) score by period (1, 3, and 6 months) and treatment group. (A) Treated cohort; (B) Patients with a preoperative BDI > 3. Values presented are adjusted mean change in score from baseline from a repeated measure analysis of covariance on changes in scores with treatment and visit as factors, treatment by visit interaction, and baseline score as covariate. A negative change shows an improvement. Error bars indicate standard errors. (∗ indicates p values < 0.05 for treatment-group difference; ▴ = placebo; • = escitalopram.) The Annals of Thoracic Surgery 2013 95, 1609-1618DOI: (10.1016/j.athoracsur.2013.02.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Change from baseline in Short Form (SF)-36 Physical Component Summary (PCS) score by period (1, 3, and 6 months) and treatment group; (A) Treated cohort; (B) Patients with a preoperative Beck Depression Inventory > 3. Values presented are adjusted mean change in score from baseline from a repeated measure analysis of covariance on changes in scores with treatment and visit as factors, treatment by visit interaction, and baseline score as covariate. A positive change shows an improvement. Error bars indicate standard errors. (∗ indicates p values < 0.05 for treatment-group difference; ▴ = placebo; • = escitalopram.) The Annals of Thoracic Surgery 2013 95, 1609-1618DOI: (10.1016/j.athoracsur.2013.02.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Change from baseline in Short form (SF)-36 Mental Component Summary (MCS) score by period (1, 3, and 6 months) and treatment group; (A) treated cohort and (B) patients with a preoperative Beck Depression Inventory > 3. Values presented are adjusted mean change in score from baseline from a repeated measure analysis of covariance on changes in scores with treatment and visit as factors, treatment by visit interaction and baseline score as covariate. A positive change shows an improvement. Error bars indicate standard errors. (∗ indicates p values < 0.05 for treatment-group difference; ▴ = placebo; • = escitalopram.) The Annals of Thoracic Surgery 2013 95, 1609-1618DOI: (10.1016/j.athoracsur.2013.02.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Change from baseline in Short Form (SF)-36 domain scores by period (1, 3, and 6 months) and treatment group; (A) treated cohort and (B) patients with a preoperative Beck Depression Inventory > 3. Values presented are adjusted mean change in score from baseline from a repeated measure analysis of covariance on changes in scores with treatment and visit as factors, treatment by visit interaction, and baseline score as covariate. A positive change shows an improvement. Error bars indicate standard errors. (∗ indicates p values < 0.05 and ∗∗ indicates p values < 0.01 for treatment-group difference.) The Annals of Thoracic Surgery 2013 95, 1609-1618DOI: (10.1016/j.athoracsur.2013.02.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions