Cell Migration, Freshly Squeezed

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Cell Migration, Freshly Squeezed Matthew D. Welch Cell Volume 160, Issue 4, Pages 581-582 (February 2015) DOI: 10.1016/j.cell.2015.01.053 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Motility Modes, Influencing Parameters, and the Initiation and Maintenance of Stable Bleb Motility Motility modes include mesenchymal motility, or various forms of amoeboid motility characterized by blebs, pseudopods, or stable blebs. These are influenced by environmental factors, including the strength of adhesion to the substrate, or the extent of physical confinement and contractility. The formation of a stable bleb is theorized to involve fluctuations in cortical contractility, followed by symmetry breaking and the formation of a bleb. Cortical flow of actin and myosin II toward the cell rear then enhances contractility in this location, stabilizing the formation of a single bleb at the front and generating force that drives migration. Cell 2015 160, 581-582DOI: (10.1016/j.cell.2015.01.053) Copyright © 2015 Elsevier Inc. Terms and Conditions