Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn's Disease  Matthias Jürgens, Jestinah M. Mahachie John, Isabelle Cleynen, Fabian Schnitzler, Herma Fidder, Wouter van Moerkercke, Vera Ballet, Maja Noman, Ilse Hoffman, Gert van Assche, Paul J. Rutgeerts, Kristel van Steen, Severine Vermeire  Clinical Gastroenterology and Hepatology  Volume 9, Issue 5, Pages 421-427.e1 (May 2011) DOI: 10.1016/j.cgh.2011.02.008 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Flow chart of study cohort. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Early normalization of CRP level is associated with better sustained response (demonstrated by Kaplan–Meier analysis). Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 Loss of response is associated with significantly higher CRP level over time. (A) All patients with clinical relapse, P = .016; (B) patients with relapse leading to stop of therapy, P < .001. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Figure 4 CRP level at baseline and at time of first endoscopy after initiation of IFX therapy with respect to mucosal healing status (**P < .030; ***P < .001). Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Figure 5 Proposed algorithm for a symptomatic patient who is a candidate for anti-TNF therapy. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 1 Baseline CRP levels and primary clinical response. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 2 Baseline CRP and clinical relapse and subsequent need for interventions. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 3 CRP level decreases significantly after start of treatment and increases at time of relapse, however, without reaching baseline levels again. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 4 Receiver operating characteristic curve of the PPV of normal CRP (<3 mg/L) for mucosal healing. Clinical Gastroenterology and Hepatology 2011 9, 421-427.e1DOI: (10.1016/j.cgh.2011.02.008) Copyright © 2011 AGA Institute Terms and Conditions