Volume 145, Issue 1, Pages (July 2013)

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Volume 145, Issue 1, Pages 96-104 (July 2013) Remission of Barrett's Esophagus With Early Neoplasia 5 Years After Radiofrequency Ablation With Endoscopic Resection: A Netherlands Cohort Study K. Nadine Phoa, Roos E. Pouw, Frederike G.I. van Vilsteren, Carine M.T. Sondermeijer, Fiebo J.W. Ten Kate, Mike Visser, Sybren L. Meijer, Mark I. van Berge Henegouwen, Bas L.A. M. Weusten, Erik J. Schoon, Rosalie C. Mallant–Hent, Jacques J.G. H.M. Bergman Gastroenterology Volume 145, Issue 1, Pages 96-104 (July 2013) DOI: 10.1053/j.gastro.2013.03.046 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Retrograde view of a normal-appearing neo-SJC on endoscopy after earlier RFA. In 1 of 4 biopsies focal IM was detected. (A) White-light; (B) NBI; and (C) directly after obtaining gastric cardia follow-up biopsies. Gastroenterology 2013 145, 96-104DOI: (10.1053/j.gastro.2013.03.046) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Flow diagram of patients progressing through the treatment and follow-up phase of the trial. Gastroenterology 2013 145, 96-104DOI: (10.1053/j.gastro.2013.03.046) Copyright © 2013 AGA Institute Terms and Conditions

Figure 3 Endoscopic resection for recurrent mucosal (T1m2) carcinoma at 5-year follow-up. (A), (B) Detection of an elevated Barrett’s island 2 cm above the neo-SCJ, on white-light and NBI. (C) Delineation and (D), (E) resection of the lesion. (F) Neo-SCJ, without visible residual BE or abnormalities 3 months after endoscopic resection. Gastroenterology 2013 145, 96-104DOI: (10.1053/j.gastro.2013.03.046) Copyright © 2013 AGA Institute Terms and Conditions

Figure 4 Kaplan–Meier plot showing the durability of CR-neoplasia after endoscopic resection and RFA for early BE neoplasia in 54 patients. Three patients with recurrent disease were considered a failure for disease-free survival, even though CR-neoplasia was re-established after endoscopic treatment. Gastroenterology 2013 145, 96-104DOI: (10.1053/j.gastro.2013.03.046) Copyright © 2013 AGA Institute Terms and Conditions

Figure 5 Proportion of patients (%) with focal intestinal metaplasia (IM) of the gastric cardia at each follow-up in relation to the number of patients visiting. There is no increased incidence observed over time. Of 19 patients with focal IM, this finding was not reproduced during subsequent endoscopies in 89% of cases. Gastroenterology 2013 145, 96-104DOI: (10.1053/j.gastro.2013.03.046) Copyright © 2013 AGA Institute Terms and Conditions