Volume 120, Issue 4, Pages (March 2001)

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Volume 120, Issue 4, Pages 834-840 (March 2001) Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome Severine Vermeire, Jack Satsangi, Marc Peeters, Miles Parkes, Derek P. Jewell, Robert Vlietinck, Paul Rutgeerts Gastroenterology Volume 120, Issue 4, Pages 834-840 (March 2001) DOI: 10.1053/gast.2001.22453 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Diagram of the X chromosome showing markers studied in (A) stage 1 and (B) stage 2. Gastroenterology 2001 120, 834-840DOI: (10.1053/gast.2001.22453) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Multipoint analysis for the 12 markers studied in the first stage (MAPMAKER/SIBS). LOD scores are shown for the overall data set, CD only, and for the different groups according to sex. A multipoint MLS of 2.4 (P = 0.0004) (2.5 in CD subgroup; P = 003) was observed in the pericentromeric region around dXs990 and dXs8096 (peak of linkage). Gastroenterology 2001 120, 834-840DOI: (10.1053/gast.2001.22453) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Exclusion mapping using the criterion of LOD-2 for a disease locus λs= 2 in the first stage and data set of 79 affected sibling pairs (MAPMAKER/SIBS). Except for the pericentromeric region of the X chromosome, the remainder of X may be excluded as containing a susceptibility gene, of λs≥2. Gastroenterology 2001 120, 834-840DOI: (10.1053/gast.2001.22453) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Multipoint analysis in stage 2 investigation involving 145 affected relative pairs (GENEHUNTER). The NPL-1 linkage support interval around the peak is shown and spans 19.7 cM. Maximum linkage is seen around dXs1203 (NPL score, 2.90; P = 0.0017). Gastroenterology 2001 120, 834-840DOI: (10.1053/gast.2001.22453) Copyright © 2001 American Gastroenterological Association Terms and Conditions