2Public Health Unit. Komfo Anokye Teaching Hospital

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2Public Health Unit. Komfo Anokye Teaching Hospital Profile of Tuberculosis patients with HIV co-infection at a teaching hospital. Kumasi Anthony Enimil1, Nicholas Karikari Mensah2, Francis Osei Adjei3, Eugenia Sly- Moore4 Evans Xorse Amuzu5, Appiah Seth Christopher6, Phans Oduro Sarpong5. 1Department of Child Health. School of Medical Sciences. Kwame Nkrumah University of Sciences and Technology. 2Public Health Unit. Komfo Anokye Teaching Hospital 3Kumasi Centre for Collaborative Research in Tropical Medicine. Kwame Nkrumah University of Sciences and Technology. 4Directorate of Child Health. Komfo Anokye Teaching Hospital 5Research and Development Unit. Komfo Anokye Teaching Hospital 6School of Sociology and Social Work-KNUST

Outline Introduction Objectives Method Results Conclusion

introduction Tuberculosis (TB) and HIV infection together constitute a significant public health concern in most developing countries There is 2.6 times higher risk of death in HIV-infected compared to uninfected children In a primary care setting reported TB case fatality was 4.3 times higher in HIV-infected than in uninfected children

Objectives The aim of the study was to describe the profile of tuberculosis patients (0-19 years) with HIV infection attending the Komfo Anokye Teaching Hospital (KATH) Paediatric and Adolescent TB Clinic, Kumasi-Ghana

Method We conducted a retrospective patient folder review of registered TB patients at the chest clinic and focused on those co-infected with HIV from January 2012 to December 2017. Data was entered into database designed with Microsoft Access, and exported into STATA for statistical analysis.

Results A total of 620 cases of TB were recorded during the period under review (January 2012 to December 2017) 43.1% (n=267) were HIV positive and 49.0% (n=131) males Median age was 5 (IQR=3-10)

Results cont.

Results cont.

Extra-pulmonary TB Site Results cont. Extra-pulmonary TB Site Abdominal 33.33% Adenitis 38.10% Pericarditis 4.76% Pleural effusion 23.81

Conclusion This study suggests a high prevalence of HIV among paediatric Tuberculosis patients. This highlights the need for intensified screening of HIV infection in tuberculosis patients and other high risk groups.

Recommendation Task shifting in screening TB patients for HIV and HIV patients for Tuberculosis. This will enhance early detection and improve treatment initiation

Acknowledgement staffs of Chest Clinic, KATH Public Health Unit KATH Research and Development Unit of KATH

Reference Russell GK,Merle CS, Cooke GS, Casas EC, Silveira da Fonseca Mdu Cros P. Towards the WHO target of zero childhood tuberculosis deaths: An analysis of mortality in 13 locations in Africa and Asia. Int J Tuberculosis Lung Dis 2013; 17: 1518–23. Henegar C, Behets F, Vanden Driessche K, Tabala M, Van Rie A. Impact of HIV on clinical presentation and outcomes of tuberculosis treatment at primary care level. Int J Tuberculosis Lung Dis 2013; 17:1411–3.