A Seminal Finding for Understanding HIV Transmission

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Presentation transcript:

A Seminal Finding for Understanding HIV Transmission Nadia R. Roan, Warner C. Greene Cell Volume 131, Issue 6, Pages 1044-1046 (December 2007) DOI: 10.1016/j.cell.2007.11.030 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Enhancement of HIV Infection by SEVI Prostatic acid phosphatase (PAP), an abundant protein in semen, is cleaved into the PAP248-286 peptide, which then aggregates to form amyloid fibrils termed semen-derived enhancer of viral infection (SEVI) (Münch et al., 2007). The fibrils capture HIV virions and direct them to target cells to which they fuse. Under conditions of a limiting viral inoculum, SEVI enhances infectivity of HIV virions by more than 100,000-fold Cell 2007 131, 1044-1046DOI: (10.1016/j.cell.2007.11.030) Copyright © 2007 Elsevier Inc. Terms and Conditions