Volume 37, Issue 4, Pages (October 2002)

Slides:

Advertisements

Similar presentations

EASL Clinical Practice Guidelines: Vascular diseases of the liver Journal of Hepatology Volume 64, Issue 1, Pages (January 2016) DOI: /j.jhep

Advertisements

Volume 46, Issue 3, Pages (March 2007)

Inflammasomes in liver diseases

Volume 65, Issue 1, Pages S2-S21 (October 2016)

Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E.

Tiny RNA with great effects: miR-155 in alcoholic liver disease

Suneet Agarwal, Anjana Rao Immunity

Mice With Human Livers Gastroenterology

Volume 44, Issue 2, Pages (February 2006)

Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins Li Li, Charles N. Falany

Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy Masahito Ikawa, Nobushige.

Matthew T. Kitson, Stuart K. Roberts Journal of Hepatology

Cohesion, but not too close

Determinants of hepatic effector CD8+ T cell dynamics

Volume 117, Issue 6, Pages (December 1999)

Heidi Barth, Eric Robinet, T. Jake Liang, Thomas F. Baumert

Volume 122, Issue 2, Pages (February 2002)

Volume 7, Issue 6, Pages (December 1997)

Analysis of the Human Ferrochelatase Promoter in Transgenic Mice

Volume 58, Issue 3, Pages (September 2000)

Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy Masahito Ikawa, Nobushige.

Volume 44, Issue 5, Pages (May 2006)

Hepatitis C core protein – The “core” of immune deception?

Volume 132, Issue 4, Pages (April 2007)

Volume 16, Issue 6, Pages (June 2002)

Burcin Ekser, Eric Lagasse Journal of Hepatology

Volume 139, Issue 4, Pages e5 (October 2010)

Volume 9, Issue 4, Pages (October 1998)

The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis

Volume 57, Issue 2, Pages (August 2012)

Approaches for treatment of liver fibrosis in chronic hepatitis C

Cryopreserved mouse hepatocytes retain regenerative capacity in vivo

Volume 39, Issue 5, Pages (November 2003)

Therapeutic editing of hepatocyte genome in vivo

Volume 37, Issue 3, Pages (September 2002)

T-Cell Large Granular Lymphocytic Leukemia and Pure Red Cell Aplasia in a Patient With Type I Autoimmune Polyendocrinopathy: Response to Immunosuppressive.

Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E.

Induced pluripotent stem cells: A new era for hepatology

Volume 41, Issue 2, Pages (August 2004)

Volume 153, Issue 4, Pages (May 2013)

Both E12 and E47 Allow Commitment to the B Cell Lineage

Volume 20, Issue 3, Pages (March 2004)

Paul C. Adams, James C. Barton Journal of Hepatology

Ludovica Bruno, Hans Jörg Fehling, Harald von Boehmer Immunity

The potential of induced pluripotent stem cell derived hepatocytes

A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development Rita M. Quintana, Adam J. Dupuy, Ana Bravo, M Llanos Casanova, Josefa.

Volume 153, Issue 4, Pages (May 2013)

Volume 74, Issue 6, Pages (September 2008)

Volume 7, Issue 1, Pages (January 2003)

Β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region M.A Bender, Michael.

Volume 42, Issue 6, Pages (June 2005)

Serum HBV pgRNA as a clinical marker for cccDNA activity

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells Wilfried Ellmeier,

Joan E Durbin, Renée Hackenmiller, M.Celeste Simon, David E Levy Cell

Volume 62, Issue 3, Pages (March 2015)

HCV animal models and liver disease

Pathogenesis of cholestatic hepatitis C

Chimeric mouse model of hepatitis B virus infection

The Effect of Distance on Long-Range Chromatin Interactions

The Herbal Medicine Sho-saiko-to Inhibits Growth and Metastasis of Malignant Melanoma Primarily Developed in ret-Transgenic Mice Masashi Kato, Wei Liu,

Volume 6, Issue 4, Pages (October 2007)

Volume 71, Issue 1, Pages (July 2019)

Volume 3, Issue 6, Pages (June 2001)

Gα12 is not required for hepatic cystogenosis induced by Pkd1 knockout

A: Representative Western blot showing a band migrating at ∼90 kDa corresponding to neprilysin protein. A: Representative Western blot showing a band migrating.

Volume 70, Issue 6, Pages (September 2006)

Volume 7, Issue 1, Pages (January 2003)

CTCF regulates cell cycle progression of αβ T cells in the thymus

Volume 36, Issue 4, Pages (November 2009)

Delivery of a Retroviral Vector Expressing Human β-Glucuronidase to the Liver and Spleen Decreases Lysosomal Storage in Mucopolysaccharidosis VII Mice

Presentation transcript:

Volume 37, Issue 4, Pages 422-424 (October 2002) Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, Degen JL. Complete hepatic regeneration after somatic deletion of an albumin–plasminogen activator transgene [Cell 1991;66:245–256] Markus Grompe Journal of Hepatology Volume 37, Issue 4, Pages 422-424 (October 2002) DOI: 10.1016/S0168-8278(02)00206-4

Fig. 1 Gross appearance of Alb-uPA transgenic mouse liver. Livers were removed from 5-week-old male mice. The liver to the left is from a non-transgenic control mouse, that in the center from a hemizygous transgenic mouse and that to the right from a homozygous transgenic mouse. Note the large red nodules in the hemizygote's liver and their absence from the homozygote's liver. (Reprinted with permission from Cell 1991;66:245–256). Journal of Hepatology 2002 37, 422-424DOI: (10.1016/S0168-8278(02)00206-4)

Fig. 2 Histopathology of Alb-uPA transgenic mouse liver. (A) Liver from a 4.5-week old non-transgenic control mouse. Note the uniform size and arrangement of the hepatocytes. (B) Liver from a 4.5-week old hemizygous transgenic spanning a red–white interface. Note the disarrayed hepatocytes of variable size in the red area (top). Hepatocytes in the white area (bottom) are generally small and show cytoplasmic vacuolization. (Reprinted with permission from Cell 1991;66:245–256). Journal of Hepatology 2002 37, 422-424DOI: (10.1016/S0168-8278(02)00206-4)

Fig. 3 Southern blot analysis of the Alb-uPA transgene. DNA was isolated from a purified population of red nodule hepatocytes. The blot was simultaneously probed with a control sequence (black arrow) and transgene specific probe (upper band in all lanes). Liver C is from a non-transgenic mouse. The kidney shows the pattern of the unrearranged locus. In all red nodules, the intensity of the transgene band is reduced. In addition the size is altered, demonstrating genomic rearrangement. (Reprinted with permission from Cell 1991;66:245–256). Journal of Hepatology 2002 37, 422-424DOI: (10.1016/S0168-8278(02)00206-4)