Chromosomes & DNA Replication

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Presentation transcript:

Chromosomes & DNA Replication

Important Scientist: Griffith Injected mice with four different pneumonia bacteria samples. disease causing = dies harmless = lives heat killed disease causing = lives heat killed disease causing + harmless = dies Some factor from the dead bacteria had “transformed” the harmless bacteria into a disease causing one. Transformation – transferring genetic information from one bacterium to another.

Griffith

Avery repeated Griffith’s experiment but used enzymes to break down the substance used in the transformation. Nucleic acid DNA stores & transmits genetic information.

Hershey & Chase Bacteriophages – virus that infects bacteria. Made of a DNA or RNA core and a protein coat. Wanted to know if the DNA or the protein coat entered the bacteria. Grew viruses containing radioactive isotopes. DNA was the genetic material.

Hershey & Chase

Cell Types Prokaryotes Eukaryotes DNA: cytoplasm a single circular DNA molecule or chromosome Eukaryotes 1000x DNA as prokaryotes DNA: nucleus several chromosomes

DNA Replication Strands are complementary because each strand can be used to make the other strand.

How DNA is Replicated Replication Fork: DNA molecule separates into two strands Each DNA strand serves as a template for the new strands Follow base pairing rule DNA polymerase: enzyme joins nucleotides proofreads each “new” DNA strand