A case of childhood bullous pemphigoid with IgG and IgA autoantibodies to various domains of BP180 Manabu Osawa, MD, Ikuko Ueda-Hayakawa, MD, PhD, Taiki.

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Presentation transcript:

A case of childhood bullous pemphigoid with IgG and IgA autoantibodies to various domains of BP180 Manabu Osawa, MD, Ikuko Ueda-Hayakawa, MD, PhD, Taiki Isei, MD, PhD, Ken Yoshimura, MD, PhD, Shunpei Fukuda, MD, PhD, Takashi Hashimoto, MD, Hiroyuki Okamoto, MD, PhD Journal of the American Academy of Dermatology Volume 70, Issue 6, Pages e129-e131 (June 2014) DOI: 10.1016/j.jaad.2013.06.006 Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Childhood bullous pemphigoid. Clinical features on the whole body (A), dorsal foot (B), and sole (C), as well as dorsal hand at higher magnification (D). Journal of the American Academy of Dermatology 2014 70, e129-e131DOI: (10.1016/j.jaad.2013.06.006) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Childhood bullous pemphigoid (BP). Immunoblot analyses. A, In normal human epidermal extracts, IgG antibodies in control pemphigus vulgaris serum (PV) reacted with the 160-kDa Dsg1 and the 130-kDa Dsg3 (lane 1), IgG antibodies in control paraneoplastic pemphigus serum (PNP) reacted with the 210-kDa envoplakin and the 190-kDa periplakin (lane 2), and IgG antibodies in control BP serum reacted with the 230-kDa BP230 and the 180-kDa BP180 (lane 3). B, IgG antibodies in control BP serum (lane 1), but not in normal control serum (lane 2), reacted with recombinant protein (RP) of BP180 NC16a domain. C, IgG antibodies in control anti-BP180 type MMP serum (lane 1), but neither IgG (lane 2) nor IgA (lane 3) antibodies in normal control serum, reacted with RP of BP180 C-terminal domain. D, IgA antibodies in control LABD serum (lane 1), but neither IgG (lane 2) nor IgA (lane 3) antibodies in normal control serum, reacted with the 120-kDa LAD-1 in concentrated HaCaT cell culture supernatants. In all analyses, IgG and IgA antibodies of sera taken from this patient (Patient) at the first visit (d0) and 10 days later (d10) were examined. Journal of the American Academy of Dermatology 2014 70, e129-e131DOI: (10.1016/j.jaad.2013.06.006) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions