Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

Slides:

Advertisements

Similar presentations

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2.

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Von Ta, MD, Andrew A. White, MD

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Margaretha A. Faber, MD, Vito Sabato, MD, Chris H

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema Sabine Zeller, MSc, Claudio Rhyner, PhD, Norbert Meyer, MD, Peter.

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Immunologic defects in 22q11.2 deletion syndrome

Aspirin-induced urticaria and angioedema, but not bronchoconstriction, associated with cysteinyl leukotriene overproduction in 2 patients with asthma

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2.

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Profile of eicosanoid generation in aspirin-intolerant asthma and anaphylaxis assessed by new biomarkers Noritaka Higashi, MD, PhD, Haruhisa Mita, PhD,

Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut Leticia Tordesillas, PhD, Adeeb H. Rahman,

Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations Keita Hirai, PhD, Toshihiro Shirai, MD, PhD, Masayuki Suzuki,

Reply The Journal of Allergy and Clinical Immunology: In Practice

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Katherine N. Cahill, MD, Jillian C. Bensko, Joshua A

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

CD203c expression on human basophils is associated with asthma exacerbation Emiko Ono, MD, PhD, Masami Taniguchi, MD, PhD, Noritaka Higashi, MD, PhD,

Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma Inge M.J. Beeren, MSc, Marjolein.

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature Jessica P. Rajan, MD, Nathan E. Wineinger,

Smoking Cessation as a Possible Risk Factor for the Development of Aspirin- Exacerbated Respiratory Disease in Smokers Hiroaki Hayashi, MD, Yuma Fukutomi,

Benjamin T. Prince, MD, Msci, Ashley L. Devonshire, MD, MPH, Kristin A

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema Marek L.

Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects William Busse, MD, Sheldon Spector, MD, Karin Rosén,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease Tanya M. Laidlaw, MD, Anya J. Cutler, Molly S.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

What is an “eosinophilic phenotype” of asthma?

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Von Ta, MD, Andrew A. White, MD

Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia Hak-Ryul Kim, MD, Chang-Duk.

Biju Thomas, MD, Robert Anthony Hirst, PhD, Mina H

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Omalizumab reduces cysteinyl leukotriene and 9α,11β-prostaglandin F2 overproduction in aspirin-exacerbated respiratory disease Hiroaki Hayashi, MD, Chihiro.

Reply Journal of Allergy and Clinical Immunology

Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors Mrinmoy Das, MSc, Caroline.

IL-4–independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease Matthew D. Woolard, PhD, R. Doug.

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Safety and efficacy of repeated monthly carboplatin desensitization

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis David W. Morris, MD, Emily M. Stucke, BA, Lisa.

Carl Hamsten, MSc, PhD, Thi Anh T

Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis Noritaka Higashi, MD, PhD, Haruhisa Mita, PhD, Hiromichi Yamaguchi,

Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma Naomi Tsurikisawa, MD, Hiroshi Saito,

Presentation transcript:

Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD, Kentaro Watai, MD, Hiroaki Hayashi, MD, Yosuke Kamide, MD, PhD, Yuma Fukutomi, MD, PhD, Kiyoshi Sekiya, MD, Takahiro Tsuburai, MD, PhD, Kazuhiko Yamamoto, MD, PhD, Masami Taniguchi, MD, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 4, Pages 1162-1164.e8 (October 2017) DOI: 10.1016/j.jaci.2017.03.036 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Comparison of the expression level of CD203c on basophils from 21 patients with AERD, 22 patients with ATA, and 11 HCs under stable condition. Spontaneous (A), anti-IgE–stimulated (B), and IL-3–stimulated (C) expression levels are presented. The data are expressed as the net MFI. The error bars indicate the SD. HC, Healthy control. *P < .05 and ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 1162-1164.e8DOI: (10.1016/j.jaci.2017.03.036) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The aspirin challenge test results. A and E, The basophil count in blood. B-D and F-H, The expression levels of CD203c on peripheral basophils in 12 patients with AERD and 7 patients with ATA. The data are expressed as the net MFI (median [interquartile]). The P values indicate comparisons relative to baseline. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology 2017 140, 1162-1164.e8DOI: (10.1016/j.jaci.2017.03.036) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Correlation analyses between spontaneous and anti-IgE–stimulated CD203c expressions (A-C), between spontaneous and IL-3–stimulated CD203c expressions (D-F), and between anti-IgE–stimulated and IL-3–stimulated CD203c expression (G-I). HC, Healthy control. Journal of Allergy and Clinical Immunology 2017 140, 1162-1164.e8DOI: (10.1016/j.jaci.2017.03.036) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Aspirin challenge test results (dot plots). A, The basophil count in blood. B-D, The expression levels of CD203c on peripheral basophils. The P values are for comparisons relative to baseline. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology 2017 140, 1162-1164.e8DOI: (10.1016/j.jaci.2017.03.036) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions