Interleukin-17: Why the Worms Squirm

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Interleukin-17: Why the Worms Squirm Noah J. Silverstein, Jun R. Huh Immunity Volume 46, Issue 3, Pages 347-349 (March 2017) DOI: 10.1016/j.immuni.2017.03.007 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The IL-17 Ortholog ILC-17.1 Modulates Neuronal Activity in RMG Interneurons Chen et al. (2017) demonstrate that the C. elegans IL-17 ortholog ILC-17.1 signals via a heterodimer of two IL-17R orthologs (ILCR-1 and ILCR-2) on RMG interneurons to produce increased neuronal activity in response to input from O2-sensing neurons exposed to 21% O2. RMG interneuron activation in npr-1-null worms leads to increased velocity of movement and to increased aggregation behavior. Immunity 2017 46, 347-349DOI: (10.1016/j.immuni.2017.03.007) Copyright © 2017 Elsevier Inc. Terms and Conditions