Should I Stay or Should I Go: Neuromodulators of Behavioral States

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Should I Stay or Should I Go: Neuromodulators of Behavioral States Alexander F. Schier Cell Volume 154, Issue 5, Pages 955-956 (August 2013) DOI: 10.1016/j.cell.2013.08.017 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Serotonin and PDF Signaling Generate Behavioral States in C. elegans (A) C. elegans worms cycle between roaming and dwelling states. Serotonin signaling promotes dwelling, whereas PDF signaling promotes roaming. (B) Schematic circuit diagram shows that some neurons (orange) are directly inhibited by serotonin, whereas other neurons (yellow) are directly activated by PDF. The two signals converge on some neurons (red) to exert opposing effects. Cell 2013 154, 955-956DOI: (10.1016/j.cell.2013.08.017) Copyright © 2013 Elsevier Inc. Terms and Conditions