Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity

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Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity Gangqing Hu, Keji Zhao Immunity Volume 45, Issue 3, Pages 459-461 (September 2016) DOI: 10.1016/j.immuni.2016.08.020 Copyright © 2016 Terms and Conditions

Figure 1 Multi-layer 3D Chromatin Reorganization during the Transition from Naive B Cells to GC B Cells Top: loss of interactions between p- and q-arms of a chromosome. Middle: merge of gene neighborhoods into gene “cities” with enhanced interactions among promotors and enhancers. Bottom: reorganization of 3D chromatin interactions centered on Bcl6 and an upstream LCR, accompanied by upregulation of GC-specific (GC-sp) transcription program. Immunity 2016 45, 459-461DOI: (10.1016/j.immuni.2016.08.020) Copyright © 2016 Terms and Conditions