The Circuit Architecture of Whole Brains at the Mesoscopic Scale

Slides:

Advertisements

Similar presentations

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Advertisements

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Intensity-Dependent Adaptation of Cortical and Thalamic Neurons Is Controlled by Brainstem Circuits of the Sensory Pathway Elad Ganmor, Yonatan Katz, Ilan.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling Priyanka Sabharwal, Changhee Lee, Sungjin Park, Meenakshi.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Rare Inherited Variation in Autism: Beginning to See the Forest and a Few Trees Jason L. Stein, Neelroop N. Parikshak, Daniel H. Geschwind Neuron Volume.

Soyoun Kim, Jaewon Hwang, Daeyeol Lee Neuron

Dynein’s Life in the Slow Lane

Jack P. Shonkoff, Pat Levitt Neuron

Signal, Noise, and Variation in Neural and Sensory-Motor Latency

Volume 82, Issue 6, Pages (June 2014)

“MAPseq”-uencing Long-Range Neuronal Projections

Madza Farias-Virgens, Stephanie A. White Neuron

Decision Making: From Neuroscience to Psychiatry

Kinesthetic information disambiguates visual motion signals

Optimal Degrees of Synaptic Connectivity

Volume 87, Issue 6, Pages (September 2015)

A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex Tomokazu Ohshiro, Dora E. Angelaki, Gregory C.

Volume 68, Issue 2, Pages (October 2010)

Emotional Pain without Sensory Pain—Dream On?

Following Directions from the Retina to the Brain

Volume 55, Issue 3, Pages (August 2007)

Aleksander Sobczyk, Karel Svoboda Neuron

Volume 96, Issue 4, Pages e5 (November 2017)

Decision Making: From Neuroscience to Psychiatry

Intrinsic and Task-Evoked Network Architectures of the Human Brain

Bringing Kids into the Scientific Review Process

Dopaminergic Modulation of Axon Initial Segment Calcium Channels Regulates Action Potential Initiation Kevin J. Bender, Christopher P. Ford, Laurence.

K+ Channel Regulation of Multicompartmental Signal Integration

Volume 90, Issue 3, Pages (May 2016)

Sparseness and Expansion in Sensory Representations

Volume 81, Issue 5, Pages (March 2014)

BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation

Volume 88, Issue 4, Pages (November 2015)

Volume 60, Issue 4, Pages (November 2008)

Feng Han, Natalia Caporale, Yang Dan Neuron

Cian O’Donnell, Terrence J. Sejnowski Neuron

Tiago Branco, Michael Häusser Neuron

Receptive-Field Modification in Rat Visual Cortex Induced by Paired Visual Stimulation and Single-Cell Spiking C. Daniel Meliza, Yang Dan Neuron Volume.

Normal Movement Selectivity in Autism

Beta and Gamma Rhythms Go with the Flow

Volume 72, Issue 6, Pages (December 2011)

Does Neuronal Synchrony Underlie Visual Feature Grouping?

Brain Canada: One Brain One Community

A Hypothalamic Switch for REM and Non-REM Sleep

Volume 87, Issue 6, Pages (September 2015)

Towards an Individualized Delineation of Functional Neuroanatomy

Dynamic Shape Synthesis in Posterior Inferotemporal Cortex

Paying Attention to the Details of Attention

Superior Colliculus Does Play Dice

The Hidden Memory of Differentiating Cells

Pharmacogenomics and Personalized Medicine in Neuropsychiatry

The Cost of Brain Diseases: A Burden or a Challenge?

Toward Functional Classification of Neuronal Types

Brain Canada: One Brain One Community

David Hubel and Torsten Wiesel

Joshua H. Jennings, Garret D. Stuber Current Biology

Presentation transcript:

The Circuit Architecture of Whole Brains at the Mesoscopic Scale Partha P. Mitra Neuron Volume 83, Issue 6, Pages 1273-1283 (September 2014) DOI: 10.1016/j.neuron.2014.08.055 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The Mesoscale as a Transitional Scale between a Microscopic Scale where Large Interindividual Differences Exist, to a Larger Scale where a Species-Typical Pattern that Is Relatively Stable across Individuals Is Observed The two schematic illustrations of distributions of neuronal somata represent two individuals, showing a transition between two brain regions (denoted in black and green) with differing densities of the neurons symbolized as filled triangles. At the microscale (top plot), the schematized density shows variations with large variations between individuals. At the mesoscopic scale (bottom plot), a smoother density is obtained that is relatively stable across individuals and shows a species-typical structure. Neuron 2014 83, 1273-1283DOI: (10.1016/j.neuron.2014.08.055) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 2 The Failure of Regional Connectivity Matrices to Capture Information about Collateral Branching Patterns, and the Utility of Retrograde Tracer Injections in Revealing Information about Such Collateral Branches. The two neuronal configurations in (A) and (D) both correspond to the same regional connectivity matrix (B and E). Nevertheless, these configurations are neurobiologically different: in (D), individual neurons from region A send branches to both regions B and C, ensuring synchrony between signals sent from the neuronal somata in A to targets in B and C. The difference can be characterized by adding a hidden node H to the connectivity matrices that represent the branch point (C and F). Double retrograde injections with two fluorescent tracers with different colors injected into the target regions, can unambiguously identify neurons sending collateral branches to regions B and C (G). A single retrograde injection into region B, if it fills the entire neuron (requiring both retrograde and anterograde transport at the branch point), can also reveal collateral branches (H). Neuron 2014 83, 1273-1283DOI: (10.1016/j.neuron.2014.08.055) Copyright © 2014 Elsevier Inc. Terms and Conditions