A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis Heidi Schaarschmidt, ME, David Ellinghaus, PhD, Elke Rodríguez, PhD, Anja Kretschmer, PhD, Hansjörg Baurecht, MSc, Simone Lipinski, PhD, Ulf Meyer-Hoffert, MD, PhD, Jürgen Harder, PhD, Wolfgang Lieb, MD, Natalija Novak, MD, Regina Fölster-Holst, MD, Jorge Esparza-Gordillo, PhD, Ingo Marenholz, PhD, Franz Ruschendorf, PhD, Norbert Hubner, PhD, Eva Reischl, PhD, Melanie Waldenberger, PhD, Christian Gieger, PhD, Thomas Illig, PhD, Michael Kabesch, MD, Xue-Jun Zhang, MD, Feng-Li Xiao, PhD, Young- Ae Lee, MD, Andre Franke, PhD, Stephan Weidinger, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 3, Pages 802-806 (September 2015) DOI: 10.1016/j.jaci.2015.01.047 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
Fig 1 Allele-specific protein-DNA interactions of rs6720763 (XIRP2). Only the probe containing the minor (Mi; risk) allele shows allele-specific protein binding (lane 10, arrow c) compared with the major (Ma) allele (lane 3). Unlabeled minor allele probes efficiently competed with labeled minor allele probes (lanes 13 and 14) in contrast to the major allele (lanes 11 and 12) or SP1 (lanes 15 and 16). Journal of Allergy and Clinical Immunology 2015 136, 802-806DOI: (10.1016/j.jaci.2015.01.047) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions