Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease Elke Rodríguez, MSc, Hansjörg Baurecht, MSc, Esther.

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Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease Elke Rodríguez, MSc, Hansjörg Baurecht, MSc, Esther Herberich, Stefan Wagenpfeil, PhD, Sara J. Brown, MD, Heather J. Cordell, BA, MSc, DPhil, Alan D. Irvine, MD, Stephan Weidinger, MD Journal of Allergy and Clinical Immunology Volume 123, Issue 6, Pages 1361-1370.e7 (June 2009) DOI: 10.1016/j.jaci.2009.03.036 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Association of FLG mutations R501X and 2282del4 and the combined genotype with increased eczema risk. Forest plots show the ORs and respective 95% CIs for the different studies included in the meta-analysis. Funnel plots show the ORs and SEs for the association. A, R501X. B, 2282del4. C, Combined genotype. Family studies are indicated by FAM in the forest plots and by open circles in the funnel plots. Journal of Allergy and Clinical Immunology 2009 123, 1361-1370.e7DOI: (10.1016/j.jaci.2009.03.036) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association of FLG polymorphisms (combined genotype) with increased eczema risk grouped by study characteristics. Journal of Allergy and Clinical Immunology 2009 123, 1361-1370.e7DOI: (10.1016/j.jaci.2009.03.036) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association of FLG polymorphisms (combined genotype) with increased risk to several asthma definitions: A, Asthma. B, Asthma with eczema. C, Asthma without eczema. Forest plots show the ORs and respective 95% CIs for the different studies included in the meta-analysis. Funnel plots show the ORs and SEs for the association. Journal of Allergy and Clinical Immunology 2009 123, 1361-1370.e7DOI: (10.1016/j.jaci.2009.03.036) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions