An estimated 10,706 AIDS cases diagnosed in 2006 were associated with injection drug use. This number includes cases in persons who were injection drug users (IDUs), sexual contacts of an IDU, or born to a mother who was an IDU or a sex partner of an IDU. More than half of the cases associated with injection drug use were in blacks (not Hispanic) (50%). Most of the remaining cases were in whites (not Hispanic) or Hispanics, although the percentage for Hispanics (22%) was almost equal to that of whites (25%). American Indians/Alaska Natives and Asians/Pacific Islanders each accounted for 1% of all cases. The data have been adjusted for reporting delays and cases without risk factor information were proportionally redistributed.