Volume 51, Issue 2, Pages (February 2007)

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Volume 51, Issue 2, Pages 416-423 (February 2007) Gene Expression Analysis for the Prediction of Recurrence in Patients with Primary Ta Urothelial Cell Carcinoma Iman J. Schultz, Kenneth Wester, Huub Straatman, Lambertus A. Kiemeney, Marko Babjuk, Jaroslav Mares, Johannes L. Willems, Dorine W. Swinkels, J. Alfred Witjes, Per-Uno Malmström, Jacques B. de Kok European Urology Volume 51, Issue 2, Pages 416-423 (February 2007) DOI: 10.1016/j.eururo.2006.07.023 Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 1 Heatmap representing the expression profiles of the 23 genes across the nonrecurrent (NR) group (n=21) and the recurrent (R) group (n=23). The genes have been ordered according to descending Mann-Whitney U p values, with the genes above the white horizontal margin being statistically significantly different (p<0.05). Expression levels: Red and blue indicate higher and lower expression relative to the median (black), respectively. European Urology 2007 51, 416-423DOI: (10.1016/j.eururo.2006.07.023) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 2 Distribution of survivin expression in the nonrecurrent (NR) group and the recurrent (R) group. The boxes represent the survivin expression interquartile range. Open triangles represent outliers. The median survivin expression level (black horizontal bar) in the NR group and the R group are (range in parenthesis), respectively, 0.22 (0.0025–4.35) and 1.96 (0.25–7.31). The difference between the two groups is statistically significant (p=0.0011). European Urology 2007 51, 416-423DOI: (10.1016/j.eururo.2006.07.023) Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 3 The performance of survivin for the identification of patients with short or prolonged recurrence-free periods. Comparison of the receiver operating characteristic curves for survivin expression between patients with long or short recurrence-free periods revealed an area under the curve of 0.79 (95%CI, 0.65–0.92). European Urology 2007 51, 416-423DOI: (10.1016/j.eururo.2006.07.023) Copyright © 2006 European Association of Urology Terms and Conditions