Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis Tali Czarnowicki, MD, Dana Malajian, BA, Avner Shemer,

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events Keiichi Yamanaka, MD, PhD, Hitoshi.

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer Tali Czarnowicki, MD, Dana Malajian, BA, Saakshi Khattri, MD,

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology Saakshi Khattri, MD, Avner.

Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence Mariya Rozenblit, BA, Mayte Suarez-Farinas,

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications Mayte.

An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis Amy S. Paller, MD, MS, Yael Renert-Yuval, MD, Maria Suprun, MPH,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional.

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis Mayte Suárez-Fariñas, PhD,

Atopic dermatitis: Age and race do matter!

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis Julia K. Gittler, BA,

The Editors' Choice Journal of Allergy and Clinical Immunology

Patient perspectives on the management of atopic dermatitis

Is 9 more than 2 also in allergic airway inflammation?

An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease Benjamin Ungar, Sandra Garcet, Juana Gonzalez, Nikhil.

Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response Suzanne Tintle, BS, Avner Shemer, MD, Mayte Suárez-Fariñas,

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing.

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling David A. Ewald, MSc, Shinji.

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells Kristine E. Nograles, MD,

Rising prevalence of asthma is sex-specific in a US farming population

Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing Mayte Suárez-Fariñas, PhD, Benjamin Ungar,

Serum from Asian patients with atopic dermatitis is characterized by TH2/TH22 activation, which is highly correlated with nonlesional skin measures Huei-Chi.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

A network-based analysis of the late-phase reaction of the skin

Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism Emma Guttman-Yassky, MD, PhD, Benjamin Ungar, BA, Shinji Noda, MD, PhD, Maria.

Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma Inge M.J. Beeren, MSc, Marjolein.

Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1 Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD,

An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease Benjamin Ungar, Sandra Garcet, Juana Gonzalez, Nikhil.

Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march Tali.

Serum tryptase levels in atopic and nonatopic children

Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K

Reply Journal of Allergy and Clinical Immunology

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis Emma Guttman-Yassky, MD, MSc, Michelle.

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

Atopic dermatitis: A practice parameter update 2012

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis Jennifer D. Hamilton, PhD, Mayte Suárez-Fariñas,

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

What is an “eosinophilic phenotype” of asthma?

Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases Nikhil Dhingra, BS, Mayte.

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer Tali Czarnowicki, MD, Dana Malajian, BA, Saakshi Khattri, MD,

Autophagy: Nobel Prize 2016 and allergy and asthma research

Advances in the approach to the patient with food allergy

Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study Giovanni B. Pajno,

New pathways for itching in patients with atopic dermatitis?

Improvement of treatment-refractory atopic dermatitis by immunoadsorption: A pilot study Michael Kasperkiewicz, MD, Enno Schmidt, MD, PhD, Yvonne Frambach,

The Editors' Choice Journal of Allergy and Clinical Immunology

Reply Journal of Allergy and Clinical Immunology

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and.

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

The Editors' Choice Journal of Allergy and Clinical Immunology

Clinical Management of Atopic Dermatitis: Practical Highlights and Updates from the Atopic Dermatitis Practice Parameter 2012 Peter A. Lio, MD, Margaret.

Macrolide antibiotics and asthma treatment

Immune pathomechanism of drug hypersensitivity reactions

Asthma: The past, future, environment, and costs

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis Andrea L. Jones, MD, Douglas Curran-Everett, PhD,

Environmental factors and eosinophilic esophagitis

Kinase inhibitors in clinical practice: An expanding world

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis Janine Bilsborough, PhD, Donald.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell.

Presentation transcript:

Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis Tali Czarnowicki, MD, Dana Malajian, BA, Avner Shemer, MD, Judilyn Fuentes-Duculan, MD, Juana Gonzalez, PhD, Mayte Suárez- Fariñas, PhD, James G. Krueger, MD, PhD, Emma Guttman-Yassky, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages 208-211 (July 2015) DOI: 10.1016/j.jaci.2015.03.032 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 ICOS, HLA-DR, and CD69 expression in CD4+ and CD8+ T-cell memory subsets in patients with AD and psoriasis. A, Higher CD4+ CLA+/CLA− ICOS expression in patients with AD compared with patients with psoriasis and controls. B, Higher CD8+ CLA+/CLA− HLA-DR expression in patients with AD compared with patients with psoriasis and controls. C, Compared with patients with AD, patients with psoriasis had significantly higher CD69 expression in CLA+ T cells. D, CD69 expression in skin-homing cells was positively correlated with PASI and negatively correlated with SCORAD. Journal of Allergy and Clinical Immunology 2015 136, 208-211DOI: (10.1016/j.jaci.2015.03.032) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Skin-homing CD25+CD127−CCR4+ Treg-cell frequency and correlation with ICOS+-activated T-cell memory subsets in patients with AD and psoriasis. A, Patients with AD showed increased frequency of CD25+CD127−CCR4+CLA+ Treg cells, which correlated positively with SCORAD (B) and IgE levels (C). D and E, AD. Significant correlations were observed between CD25+CD127−CCR4+CLA+ Treg cells and CLA+ICOS+ Tcm/Tem subsets. F and G, Psoriasis. Nonsignificant correlations were observed between CD25+CD127−CCR4+CLA+ and ICOS expression in both Tcm and Tem subsets. Journal of Allergy and Clinical Immunology 2015 136, 208-211DOI: (10.1016/j.jaci.2015.03.032) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions