Probiotics in Transition

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Presentation transcript:

Probiotics in Transition Fergus Shanahan, Timothy G. Dinan, Paul Ross, Colin Hill Clinical Gastroenterology and Hepatology Volume 10, Issue 11, Pages 1220-1224 (November 2012) DOI: 10.1016/j.cgh.2012.09.020 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Probiotic rationale in settings of low microbial diversity. Low microbial diversity favors ingress of pathogens and limits the protective signaling from the microbiota to the host; host-microbe mismatch may also arise with bacterial overload such as might occur in undeveloped countries. (modified with permission from Shanahan6) Clinical Gastroenterology and Hepatology 2012 10, 1220-1224DOI: (10.1016/j.cgh.2012.09.020) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Probiotic strategy when mimicking a specific beneficial effect of the commensal microbiota is desired. (modified with permission from Shanahan6) Clinical Gastroenterology and Hepatology 2012 10, 1220-1224DOI: (10.1016/j.cgh.2012.09.020) Copyright © 2012 AGA Institute Terms and Conditions