The Liver as a Hub in Thermogenesis

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The Liver as a Hub in Thermogenesis Nada A. Abumrad Cell Metabolism Volume 26, Issue 3, Pages 454-455 (September 2017) DOI: 10.1016/j.cmet.2017.08.018 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Liver as a Thermogenic Hub During cold exposure, FAs from hepatic VLDL are rapidly extracted by BAT. Adrenergic stimulation activates hepatic gluconeogenesis, providing glucose for BAT thermogenesis, and early evidence also suggests that the liver might contribute to heat generation in cold-exposed rodents. In this issue of Cell Metabolism, Simcox et al. (2017) show that FAs mobilized from cold stimulation of WAT activate HNFα in the liver, leading to increased FA oxidation and the production of acylcarnitines that serve to further fuel BAT metabolism and NST. Cell Metabolism 2017 26, 454-455DOI: (10.1016/j.cmet.2017.08.018) Copyright © 2017 Elsevier Inc. Terms and Conditions