A, representative gross feature of a gastric cancer (arrows), an ulceroinfiltrative mass in the antral mucosa, arising in Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+

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A, representative gross feature of a gastric cancer (arrows), an ulceroinfiltrative mass in the antral mucosa, arising in Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+ mice (ii). A, representative gross feature of a gastric cancer (arrows), an ulceroinfiltrative mass in the antral mucosa, arising in Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+ mice (ii). Gastric lumen of a Pdx-1-Cre–negative mouse of the same age (i). B, representative histologic findings of the gastric cancer (i) and lymph node metastasis (ii). Boxed regions of left panels are shown at higher magnification in the right panels. C, representative E-cadherin immunohistochemical staining of gastric adenocarcinomas arising in Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+ mice at 6 and 9 months of age (i). ii, Gastric adenocarcinoma arising in a Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1+/+ mouse. D, gastric adenocarcinoma-free survivals of Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+ (n = 25) compared with Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1+/+ mice (n = 28). Jun Won Park et al. Mol Cancer Res 2014;12:1088-1099 ©2014 by American Association for Cancer Research