The Testosterone Two-Step Is Really a Minuet

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The Testosterone Two-Step Is Really a Minuet Dwayne K. Hamson, Cynthia L. Jordan, S. Marc Breedlove Neuron Volume 66, Issue 2, Pages 167-169 (April 2010) DOI: 10.1016/j.neuron.2010.04.025 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Two Systems Interact to Masculinize the Mammalian Brain Testicular androgens such as testosterone (T) act on androgen receptors (ARs) to masculinize the body and brain (dashed arrows). However, the enzyme aromatase converts T to estrogens, which then act on estrogen receptors (ERs), and the present paper confirms that this pathway (solid arrows) is primarily responsible for masculinizing both reproductive and territorial behaviors in mice. They also find that AR acting in the brain potentiates those behaviors. The two systems of steroid receptors interact (dotted lines), as AR stimulation has been shown to boost brain aromatase in many previous reports, and the present paper indicates that ER stimulation boosts AR expression in the neonatal brain of mice. Neuron 2010 66, 167-169DOI: (10.1016/j.neuron.2010.04.025) Copyright © 2010 Elsevier Inc. Terms and Conditions