Toward a major risk factor for atopic eczema: Meta-analysis of filaggrin polymorphism data  Hansjörg Baurecht, MSc, Alan D. Irvine, MD, Natalija Novak, MD, Thomas Illig, PhD, Bettina Bühler, MSc, Johannes Ring, MD, Stefan Wagenpfeil, PhD, Stephan Weidinger, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 6, Pages 1406-1412 (December 2007) DOI: 10.1016/j.jaci.2007.08.067 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Association of FLG mutations R501X and 2282del4 (combined genotype) with increased AE risk. Forest plots showing the ORs and respective 95% CIs for the different studies (given by first author, year, and ethnicity of the study population) included in the meta-analysis are shown: A, case-control studies; B, family studies; C, combined analysis. The rhombus designates the overall estimate of all studies. The consistently higher AE risk conferred by FLG null alleles in all studies is reflected by a high overall estimated OR. GER, Germany; UK, United Kingdom; DEN, Denmark; SCO, Scotland; IRL, Ireland; cc, case control study. Journal of Allergy and Clinical Immunology 2007 120, 1406-1412DOI: (10.1016/j.jaci.2007.08.067) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Funnel plots showing the ORs and 95% CIs for the association between FLG mutations R501X and 2282del4 (combined genotype) and AE observed in case-control studies (A), family studies (B), and both study types (combined analysis; C). Tests of asymmetry showed no significant deviation from the symmetry assumption (Fig 2, A, P = .973; Fig 2, B, P = .953; Fig 2, C, P = .199), thus not indicating publication bias. Journal of Allergy and Clinical Immunology 2007 120, 1406-1412DOI: (10.1016/j.jaci.2007.08.067) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions