Volume 11, Issue 2, Pages 147-152 (August 2012) Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types  Craig J. Taylor, Sarah Peacock, Afzal N. Chaudhry, J. Andrew Bradley, Eleanor M. Bolton  Cell Stem Cell  Volume 11, Issue 2, Pages 147-152 (August 2012) DOI: 10.1016/j.stem.2012.07.014 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Ability of HLA Homozygous Donors to Provide a Zero HLA Mismatch for HLA Heterozygous Recipients (A) Potential for a panel of 405 theoretical homozygous HLA combinations to provide a zero HLA mismatch for all 10,000 potential UK recipients. The cumulative percentage of recipients matched increased steeply with successive theoretical homozygous HLA combinations ranked for utility, until the panel exceeded 100–150 combinations. (B) Ability of an iPSC bank comprising the minimum number of optimal homozygous HLA types (236) known to exist (as volunteer HSC donors on the BMDW registry) to provide a zero HLA mismatch for all 10,000 potential UK recipients. The 236 homozygous HLA types were identified among the 405 theoretical homozygous HLA combinations used in panel (A). Again, the cumulative percentage of recipients matched increased steeply with successive homozygous HLA combinations ranked for utility, but did not exceed 96% due to the absence of certain theoretical homozygous HLA combinations among the >17 million volunteers on the BMDW registry. Cell Stem Cell 2012 11, 147-152DOI: (10.1016/j.stem.2012.07.014) Copyright © 2012 Elsevier Inc. Terms and Conditions