Opening Activity: June 4, 2018 Have your idea journal for “Alleles and Chromosomes” available to stamp. Review the lab materials at your table. (Lab #20 procedure and baggie of proteins). Review your work from Thursday: What is the difference between a functional and non-functional hemoglobin molecule. How might each protein above respond to water? I can… How is it determined what chromosomes a parent passes to their offspring? Homework: Retake Test Corrections due June 5th. Test Retake 6/7, 6/8 & 6/12 @ 8am. Inheritance Quiz Monday June 11th

Today’s Goals Complete Lab #20 – draw out cells for all protein combinations. STAMP! Work on Idea Journal for “Protein Folding for Sickle Cell”. Making Sex Cells: Card Sort & Questions Pick up materials at front table. Sort the cards from a cell before cell division to the end of cell division. Draw picture of each cell in space provided.

Opening Activity: June 5, 2018 If you completed a test retake ticket - Turn into the basket and sign up for a test retake time. Have your Idea Journal for “Protein Folding” complete and ready for a stamp. There were a few people gone for Lab #20. In 1-2 sentences, what was the gist of the lab. What should you walk away knowing? Pick up Two handouts at front table – tape in. I can… explain how chromosomes are passed to their offspring Homework: Retake Test Corrections due June 5th. Test Retake 6/7, 6/8 & 6/12 @ 8am. Inheritance Quiz Monday June 11th

Making Sex Cells: Card Sort & Questions Pick up materials at front table. Sort the cards from a cell before cell division to the end of cell division. Draw picture of each cell in space provided.

Meiosis Card Sort Questions Label where crossing over happens. Label where independent assortment happens. There are 2 small and 2 large chromosomes in each cell in image 1 and image 7. But they are not the same! Describe the differences. How does the number of chromosomes compare in cell 1 and cell 11? There are 4 cells in image 11. What is similar about all 4 cells? What is different? What do the 4 cells in image 11 become if this happened in a female? In a male?

Opening Activity: June 6, 2018 Sorry I am not here today, but you will continue the work on your Chirwibble! Can you figure out how the chirwibble’s traits get passed down to their offspring? Find your chirwilbble work and draw your chirwilbble on step 1. Find your chromosomes, whiteboard and pens/erasers so you are ready to start. You will only need TWO sets of chromosomes at your table. Put any extra chromosomes in the bin at the front table. I can…predict the traits of offspring Homework: Test Retake 6/7, 6/8 & 6/12 @ 8am. Inheritance Quiz Monday June 11th

Today’s Goals Use the paper models to see HOW the gametes all end up different (steps 2-5). Work with a partner. Each table needs to do this twice: once for the mother, once for the father. (half of you will keep track of Mom’s gametes and half you will keep track of Dad’s gametes). FOLLOW INSTRUCTIONS!!! There are a lot of steps, so you need to read carefully. Have one person in each partnership be responsible for reading the instructions out loud. Yes on step 3 you will do some cutting and taping as you model “Crossing Over”. Work on Fertilization and Analysis Questions.

Opening Activity: June 7, 2018 If you did not finish Lab 21 yesterday, please continue working now and I will stamp! If you have questions please ask! If you are done: Find your initial idea (family tree) and determine what genotype each individual would have. Pick up a your class questions at front table. Which questions can you now answer? I can… How can we predict the traits of offspring? Homework: Read Intro for Lab #23 & Prediction Test Retake 6/8 & 6/12 @ 8am. Inheritance Quiz Monday June 11th

What can you add to the model?

How are genes passed through the generations?

Idea Journal

So how do we pass on only half our alleles? Quick recap of meiosis Lab #22 Predicting Traits

Lab #22 Predicting Traits – Use egg and sperm charts to determine possible genotypes and phenotypes of offspring. 1. Fill out the table in Part 1 of the worksheet Which finger on top?

Look at the cherwibbles! Focus on the COLOR – what do you notice? Is it random? Or can we predict the probability a cherwibble will be green or yellow?

Parent Genotype and Phenotype Genotype: Gg Phenotype: Green G g

Possible Offspring Genotype and Phenotype Genotype: gg Phenotype: Yellow g

Determining offspring genotypes Remember from meiosis – half the gametes get one allele, half the gametes get the other So, half get G and half get g G g G G g g

Possible Combinations Mother (Gg) Father (Gg) G g G g G G g g G G g g G G g G g g

Possible Combinations Mother (Gg) Father (Gg) G g G g G GG = green G g Gg = green G g Gg = green g gg = yellow = non-functional

Egg and sperm charts organize all possible offspring combinations Mother (Rr) Father (Rr) G g G g x g G G g R G GG Gg r g Gg gg

Genotype probabilities Phenotype probabilities Egg and sperm charts predict probability of all genotypes and phenotypes produced G g GG Gg gg Genotype probabilities 25% GG 50% Gg 25% gg Phenotype probabilities 75% green 25% yellow

What about fur? F f F FF Ff f Ff ff sperm Mother (Ff) Father (Ff) x eggs f Ff ff Parents Curly fur Straight Fur Ff x Ff 3 1

What about this one? f f F Ff Ff F Ff Ff sperm Mother (FF) Father (ff) x F Ff Ff eggs F Ff Ff Parents Curly fur Straight Fur FF x ff 4

What about this one? f f F Ff Ff f ff ff sperm Mother (Ff) Father (ff) x F Ff Ff eggs f ff ff Parents Curly fur Straight Fur FF x ff 2

Now your turn!

HOMEWORK: Prepare for Lab #23 Read through background information Make predictions

Lab #23 Review the graphs – any relationships to take note?

Opening Activity: June 8, 2018 Have Lab #23 predictions ready for stamp. Pick up Inheritance unit checklist Question for you. What would be most helpful for you and your learning today: Do lab #23 - learn about Sickle alleles in populations. Review the ideas of lab #23 as a group and spend the day working on idea journal, questions and initial ideas. WRITE YOUR ANSWER (A or B) on ¼ sheet of paper from front table and put into the bin at front table. I can…Explain why the sickle cell disease is still in the population. Homework: Test Retake 6/8 & 6/12 @ 8am. Inheritance Quiz Monday June 11th

Lab #23 Review the graphs – any relationships to take note?

Number of A and S alleles surviving to the next generation High Malaria Parents F1 F2 F3 A S Class Total  400 400 227  173 244 156 252 148 Allele Frequency %  50% 50% 56% 43% 61% 39% 63% 37% Low Malaria Parents F1 F2 F3 A S Class Total  400 400 315 164 282 116 316 84 Allele Frequency %  50% 50% 66% 34% 71% 29% 79% 20%

Pd 4 Number of A and S alleles surviving to the next generation High Malaria Parents F1 F2 F3 A S Class Total Allele Frequency % Low Malaria Parents F1 F2 F3 A S Class Total 200 48 28 44 16 40 10 Allele Frequency %

Questions List the trends for the following: HbS allele and high malaria HbA allele in high malaria HbS allele and low malaria HbA allele in low malaria Compare the data from the two tables – any similarities/differences. Why does the US have a lower HbS allele than Africa?