The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes V.B. Kraus, M.D., Ph.D., J.M. Jordan,

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The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes V.B. Kraus, M.D., Ph.D., J.M. Jordan, M.D., M.P.H., M. Doherty, M.D., M.P.H., A.G. Wilson, M.D., Ph.D., R. Moskowitz, M.D., Ph.D., M. Hochberg, M.D., M.P.H., R. Loeser, M.D., M. Hooper, M.D., J.B. Renner, M.D., M.M. Crane, Ph.D., P. Hastie, M.P.H., S. Sundseth, Ph.D., U. Atif, Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 2, Pages 120-127 (February 2007) DOI: 10.1016/j.joca.2006.10.002 Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 The number of individuals with specified patterns of hand rOA. The patterns of hand rOA are shown for the 1963 participants meeting GOGO gold standard hand rOA criteria. (A) Number of joints involved for the patterns DIP/PIP, DIP/PIP/MCP, and DIP/MCP/CMC-1; (B) numbers of joints involved for the patterns DIP/PIP/CMC-1, DIP/PIP/MCP/CMC-1, and DIP/CMC-1. One participant had only DIP involvement with three total affected joints (not shown). Osteoarthritis and Cartilage 2007 15, 120-127DOI: (10.1016/j.joca.2006.10.002) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Frequency of multiple joint involvement with OA. The frequencies of rOA at various sites, and sites in combination, are shown for the US in light gray, and for the UK in dark gray for the 1963 participants meeting GOGO gold standard hand rOA criteria. The groups represented are mutually exclusive. The frequencies of one joint site (hand only), two sites (hand/knee and hand/hip) or three sites (hand/knee/hip) are shown. The frequency of spine OA in combination with the aforementioned phenotypes is indicated by the stippled bars. Because the US sites were the only ones to perform lumbar spine radiography, these stippled bars, representing spine OA frequencies, are only found above the bars representing US frequencies. Osteoarthritis and Cartilage 2007 15, 120-127DOI: (10.1016/j.joca.2006.10.002) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions