Regulation of gene expression by FACT.

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Regulation of gene expression by FACT. Regulation of gene expression by FACT. (A) MTT assay assessing cell metabolic activity in mESCs at different cell densities following depletion of FACT levels. Values are mean and SE of three independent transfection experiments are displayed. Significance was calculated via a two-tailed t test (P < 0.05). (B) Volcano plot of differentially expressed genes between the control and KD group. Values with logFC > 1 or logFC < −1 and adjusted P-value < 0.01 are highlighted in red. (C) Gene ontology analysis of all differentially expressed genes (red: pathways for down-regulated genes and blue: pathways for up-regulated genes). (D) Scatterplot of log (SSRP1 coverage) (ChIP-seq) over logFC (RNA-seq). Numbers for up-, down-, and non-changing genes are given. Correlation between SSRP1 coverage and gene expression change (fold change) is indicated by the dashed line. Constantine Mylonas, and Peter Tessarz LSA 2018;1:e201800085 © 2018 Tessarz and Mylonas