Dasatinib-Induced Colitis after Allogeneic Stem Cell Transplantation for Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Ibrahim Aldoss,

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Dasatinib-Induced Colitis after Allogeneic Stem Cell Transplantation for Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Ibrahim Aldoss, Karl Gaal, Monzr M. Al Malki, Haris Ali, Ryotaro Nakamura, Stephen J. Forman, Vinod Pullarkat Biology of Blood and Marrow Transplantation Volume 22, Issue 10, Pages 1900-1903 (October 2016) DOI: 10.1016/j.bbmt.2016.06.022 Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Colon biopsies in DIC, acute GVHD, and CMV colitis. All biopsies show similar histologic findings with scattered apoptotic bodies in glandular crypts (red arrows) and mild chronic inflammatory infiltrate. In addition, reddish intranuclear inclusions (black solid arrow) are seen in CMV colitis, confirmed by CMV immunostain (inset) (H&E, ×60, CMV immunohistochemistry, ×60). Biology of Blood and Marrow Transplantation 2016 22, 1900-1903DOI: (10.1016/j.bbmt.2016.06.022) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Characterization of lymphocytic infiltrates in DIC and acute GVHD. Both biopsies show similar infiltration in lamina propria and crypt epithelia of predominantly CD3 and CD8-positive cytotoxic T cells. CD56-positive natural killer cells are rare in the epithelium. (CD3, ×60; CD8, ×60; CD56, ×60). Biology of Blood and Marrow Transplantation 2016 22, 1900-1903DOI: (10.1016/j.bbmt.2016.06.022) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions