Biochemical pathways proximal to the IDH1 and IDH2 reactions.

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Biochemical pathways proximal to the IDH1 and IDH2 reactions. Biochemical pathways proximal to the IDH1 and IDH2 reactions. IDH1 is located in the cytoplasm and peroxisomes, whereas IDH2 is located in the mitochondrial matrix. The reactions catalyzed by these enzymes are linked to metabolites involved in amino acid metabolism, particularly that of glutamine and glutamate, and in fatty acid synthesis and the TCA cycle. IDH1 and IDH2 activities also affect the cytoplasmic and mitochondrial ratio of NADP/NADPH, a major source of reducing potential. Rob A. Cairns, and Tak W. Mak Cancer Discovery 2013;3:730-741 ©2013 by American Association for Cancer Research