Focus of research group (I)

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Presentation transcript:

Focus of research group (I) Name PI: Vincent Christoffels Department, UMC: Medical Biology, AMC Size of research group: 3 senior researchers, 2 postdocs, 6 PhD students, 3 technicians Current mission, vision and aims Mission: To explore the transcriptional regulation of heart development, rhythm and regeneration. Vision: One day we will understand the relation between genotype and cardiac phenotype (congenital heart defects, arrhythmia, etc.). Research is fueled by curiosity. Aims: To understand the development of heart cells and components, including pacemaker and conduction system. To understand relation between gene regulation and function. To understand the relation between genomic variation, gene regulation and disease predisposition.

Focus of research group (II) Current expertise (Heart) Development Transgenesis / CRISPR-based genome editing in vivo Transcriptional regulation Epigenomics (RNA-seq, ChIP-seq, ATAC-seq, 4C-seq) Current funding Leducq NHS CVON ZonMW TOP Charles River grant

Future plans Short term (1-2 year) plan Plan: Study role of Tbx3 in SAN and AV conduction system regulation. Clarify the mechanistic link between Tbx5 gain of function and AF predisposition. Explore the in vivo function of non-coding variant regulatory sequences associated with AF and conduction. Optimize CRISPR mediated genome editing (KI) in mouse in vivo. Identify and characterize regulatory DNA elements driving MI/injury response, atrial- and conduction system-specific expression. Necessary infrastructure: Mouse transgenesis facility, experimental animal facility, state of art electrophysiology analysis set up, genomics facility

Future plans Long term (>2 year) plan Plan: Explore the precise genomic mechanisms underlying function of genetic variation associated with cardiac defects and disease in vivo. Move towards human cell models Explore new transcriptional and epigenetic regulatory mechanisms for development and homeostasis Necessary infrastructure: Human stem cell / genetic modification unit Genomics facility (sc seq etc.) Bioinformatics Genome editing Functional imaging / microscopy Electrophysiology Collaboration in ACS Exp. Cardiol. AMC; Klin. Genetics.