Mice null for the alternatively spliced EDA segment of fibronectin exhibit reduced knee inflammation after tibial compression injury J. Peters, J. Fong,

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Mice null for the alternatively spliced EDA segment of fibronectin exhibit reduced knee inflammation after tibial compression injury J. Peters, J. Fong, Y. Arabi, B.A. Christiansen, D.R. Haudenschild Osteoarthritis and Cartilage Volume 22, Pages S255-S256 (April 2014) DOI: 10.1016/j.joca.2014.02.487 Copyright © 2014 Terms and Conditions

Fig.1. Immunohistochemistry with anti-Fn shows equivalent total fibronectin expression in wt and FnEDAIII+/+ and FN-EDAIII −/− transgenic mice. Osteoarthritis and Cartilage 2014 22, S255-S256DOI: (10.1016/j.joca.2014.02.487) Copyright © 2014 Terms and Conditions

Fig. 2 Left: MicroCT and PET image of Injured EDAIII−/− and WT mice. Right: Quantification of PET signal (n = 5). Osteoarthritis and Cartilage 2014 22, S255-S256DOI: (10.1016/j.joca.2014.02.487) Copyright © 2014 Terms and Conditions

Fig. 3 Top: In-vivo imaging of Inflammatory Cell activity (quantified ProSense signal). Bottom: In-vivo imaging of Bone Remodeling Activity (quantified CatK signal). Osteoarthritis and Cartilage 2014 22, S255-S256DOI: (10.1016/j.joca.2014.02.487) Copyright © 2014 Terms and Conditions

Fig. 4 Top: MicroCT quantified 7 days after injury, shows consistent loss of subchondral trabecular bone volume upon injury in all genetic backgrounds. EDAIII−/− mice had slightly higher bone density than WT mice. Bottom: As a percentage of total bone, the Fibronectin EDAIII transgenic mice lost less bone than WT mice. Osteoarthritis and Cartilage 2014 22, S255-S256DOI: (10.1016/j.joca.2014.02.487) Copyright © 2014 Terms and Conditions