Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action D.A. Payne, FRCS(Ed)a,

Slides:

Advertisements

Similar presentations

Ticlopidine (Ticlid™) and Clopidogrel (Plavix™) Benedict R. Lucchesi, M.D., Ph.D. Department of Pharmacology University of Michigan Medical School.

Advertisements

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.

I may not be Southern by birth, but I am proud to be an American: The role of international medical graduates in vascular surgery and the Southern Association.

Volume 124, Issue 2, Pages (June 2009)

Volume 124, Issue 2, Pages (June 2009)

Anti-platelet effect of aspirin is substantially reduced after administration of heparin during carotid endarterectomy Sally E. Webster, MB, BS, David.

Arterioscler Thromb Vasc Biol

The antithrombotic effect of aprotinin: actions mediated via the protease-activated receptor 1 Michael Poullis, FRCSa, Richard Manning, BScb, Mike Laffan,

Recurrent thromboembolism in patients with vena cava filters

Ergotism associated with HIV antiviral protease inhibitor therapy

Yuji Hiramatsu, MDa, Nicolas Gikakis, BSEa, Harry L

Vessel loops made easy Journal of Vascular Surgery

Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time Douglas B Wilhite, MD, Anthony J Comerota, MD, Frank.

Jian-ming Li, MDa, Charles S. C. Garnette, MDa, Mitchell Cahn, MDa, R

Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties Carolyn A.

Asymptomatic internal carotid artery aneurysm

Occam's razor: Intervene early to prevent more strokes!

Rat and human aortic smooth muscle cells display differing migration and matrix metalloproteinase activities in response to dexamethasone C. Pross, MD,

Chris I. Jones, PhD, David A. Payne, FRCS, Paul D. Hayes, MD, A

Breakthrough: Arthur Blakemore and Arthur Voorhees, Jr

Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition

Severe bleeding as a result of platelet inhibition caused by floxacillin treatment for endocarditis Juliane Rau, MD, Mark Simon, MD, Michael Sander,

Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood.

Effect of anticoagulation on endothermal ablation of the great saphenous vein Mohsen Sharifi, MD, Mahshid Mehdipour, Curt Bay, PhD, Farnaz Emrani, BS,

Flow cytometric assessment of platelet function in patients with peripheral arterial occlusive disease Spencer W. Galt, MD, Martha D. McDaniel, MD, Kenneth.

David J. Effeney, M.B., F.R.A.C.S. Journal of Vascular Surgery

Jurgen C. de Graaff, MDa, Dirk Th. Ubbink, MD, PhDa, Dink A

Relationship of severity of lower limb peripheral vascular disease to mortality and morbidity: A six-year follow-up study Mary A. Howell, MD, Mary Paula.

Does female gender or hormone replacement therapy affect early or late outcome after carotid endarterectomy? John S. Lane, MDa, Shant Shekherdimian,

Reduction of bleeding after heart operations through the prophylactic use of epsilon- aminocaproic acid Thomas J. Vander Salm, MDa, Shubjeet Kaur, MDb,

Malcolm O. Perry, MD, Richard Kempczinski, MD

Aortic aneurysm resulting from umbilical artery catheterization: Case report, literature review, and management algorithm Jeffrey Mendeloff, MD,a, Anthony.

Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients Justin Saunders, MD, Vijay Nambi, MD, Kay T.

Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography®

Peripheral vascular brachytherapy

Circulating inflammatory cells are associated with vein graft stenosis

Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational.

Infrainguinal revascularizations in octogenarians and septuagenarians

Recurrent thromboembolism in patients with vena cava filters

Effect of preoperative P2Y12 and thrombin platelet receptor inhibition on bleeding after cardiac surgery M. Ranucci, D. Colella, E. Baryshnikova, U.

A prospective randomized trial comparing vein with polytetrafluoroethylene in above- knee femoropopliteal bypass grafting Desiree H.C. Burger, MDa, A.Pieter.

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

Update in preoperative risk assessment in vascular surgery patients

Benefits, morbidity, and mortality associated with long-term administration of oral anticoagulant therapy to patients with peripheral arterial bypass.

Dual antiplatelet therapy (clopidogrel and aspirin) is associated with increased all-cause mortality after carotid revascularization for asymptomatic.

Perioperative monitoring of platelet function in paediatric cardiac surgery by thromboelastometry, or platelet aggregometry?† B.S. Romlin, F Söderlund,

Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous-flow left ventricular assist device: A.

Endoscopic versus open subfascial division of incompetent perforating veins in the treatment of venous leg ulceration: Long-term follow-up Johannes E.M.

Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans

Michael E. Landis, MDa, Edward C

Reviewer Acknowledgment

Journal of Vascular Surgery Volume 34, Issue 6, Pages (December 2001)

Skin perfusion pressure of the foot is a good substitute for toe pressure in the assessment of limb ischemia Felix W. Tsai, MDa, Nirman Tulsyan, MDa,

Ipsilateral femoral vein compression: A contraindication to thrombin injection of femoral pseudoaneurysms Benjamin Hung, MD, a, Bertrand Gallet, MD,

Calvin B. Ernst, MD Journal of Vascular Surgery

Patients' thromboembolic potential after carotid endarterectomy is related to the platelets' sensitivity to adenosine diphosphate Paul D Hayes, FRCS,

Aspirin resistance after coronary artery bypass grafting

Cardiovascular surgery—The rocket and its stars: Presidential address

Erratum Experimental Hematology

Gary W. Barone, MD, Axel W. Joob, MD, Terry L. Flanagan, MPH, Carey E

A. Hofer, S. Kozek-Langenecker, E. Schaden, M. Panholzer, H. Gombotz

Darrell N. Jones, PhD, Robert B

Substitution by adenosine for glucagon as a surgical diagnostic tool to detect mesenteric vascular adaptation István Dóbi, MD, Alexander Juhász-Nagy,

Increased amount of type III pN-collagen in human abdominal aortic aneurysms: Evidence for impaired type III collagen fibrillogenesis Michaela K. Bode,

Outcomes after surgery for thoracic outlet syndrome

Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries Kimihiro Komori, MD, Hiroaki Shimokawa,

The Propranolol Aneurysm Trial Investigators

James A. DeWeese, MD Journal of Vascular Surgery

Estrogen improves endothelial function

Presentation transcript:

Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action D.A. Payne, FRCS(Ed)a, P.D. Hayes, FRCS(Ed)a, C.I. Jones, MScb, P. Belham, RGNb, A.R. Naylor, MDa, A.H. Goodall, PhDb Journal of Vascular Surgery Volume 35, Issue 6, Pages 1204-1209 (June 2002) DOI: 10.1067/mva.2002.122027 Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Template bleeding time measurements in healthy subjects (n = 7) given aspirin (150 mg), aspirin (150 mg/day) and clopidogrel (75 mg/day; Asp+C75) for 2 days, and aspirin (150 mg) and clopidogrel (300 mg; Asp+C300). Results are expressed as mean ± standard error of mean. Journal of Vascular Surgery 2002 35, 1204-1209DOI: (10.1067/mva.2002.122027) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Effects of aspirin alone or in combination with low dose (2 × 75 mg; C75) or high dose (300 mg; C300) clopidogrel on platelet aggregation in response to adenosine diphosphate (ADP; 10−6 mol/L), collagen (1.0 × 10−3 g/mL), and thrombin receptor agonist peptide (TRAP; 6 × 10−6 mol/L). Results are expressed as mean ± standard error of mean. Journal of Vascular Surgery 2002 35, 1204-1209DOI: (10.1067/mva.2002.122027) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Effects of aspirin alone or in combination with low dose (2 × 75 mg; C75) or high dose (300 mg; C300) clopidogrel on platelet activation markers in response to adenosine diphosphate (ADP; 10−6 mol/L) and thrombin receptor agonist peptide (TRAP; 6 × 10−6 mol/L), measured with whole blood flow cytometry. Results are expressed as mean ± standard error of mean. Journal of Vascular Surgery 2002 35, 1204-1209DOI: (10.1067/mva.2002.122027) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Adenosine diphosphate (ADP)-induced platelet fibrinogen binding, measured with whole blood flow cytometry. Measurements were made at baseline (continuous line), after aspirin therapy alone (dotted line), or with aspirin therapy in combination with low dose (2 × 75 mg; dashed line) or high dose (300 mg; dashed/dotted line) clopidogrel bisulfate. Subjects are divided into those with lower than average response to ADP (low ADP responders; n = 3) and those with higher than average response to ADP (high ADP responders; n = 4). Data are shown as mean ± standard error of mean. Journal of Vascular Surgery 2002 35, 1204-1209DOI: (10.1067/mva.2002.122027) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions